Doublecortin 产品
(Doublecortin (DCX))
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This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ('double cortex' syndrome) in females and lissencephaly ('smooth brain' syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010].
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Featured Doublecortin Categories
Doublecortin 抗体
High quality antibodies with extensive validation data.
Doublecortin ELISA试剂盒
Reliable ELISA kits for a wide range of species.
Doublecortin 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Doublecortin 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, ICC, FACS
Validations
- (1)
- (7)
Cat. No.
ABIN969513
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF
Validations
- (5)
Cat. No.
ABIN625829
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, FACS, IF/ICC
Validations
- (8)
Cat. No.
ABIN1844030
Quantity
100 μL
Datasheet
Datasheet
Recommended Doublecortin ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955452
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955453
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955454
Quantity
96 tests
Datasheet
Datasheet
Recommended Doublecortin 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1351244
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122702
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Rat
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7396373
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our Doublecortin Products
: "Regulation of the p75 neurotrophin receptor attenuates neuroinflammation and stimulates hippocampal neurogenesis in experimental Streptococcus pneumoniae meningitis." in: Journal of neuroinflammation, Vol. 18, Issue 1, pp. 253, (2022) (PubMed).: "LC-MS/MS identification of doublecortin as abundant beta cell-selective protein discharged by damaged beta cells in vitro." in: Journal of proteomics, Vol. 80, pp. 268-80, (2013) (PubMed).
: "Properties of doublecortin-(DCX)-expressing cells in the piriform cortex compared to the neurogenic dentate gyrus of adult mice." in: PLoS ONE, Vol. 6, Issue 10, pp. e25760, (2011) (PubMed).
: "Granulocyte colony-stimulating factor increases the therapeutic efficacy of bone marrow mononuclear cell transplantation in cerebral ischemia in mice." in: BMC neuroscience, Vol. 12, pp. 61, (2011) (PubMed).
: "MiR-128 up-regulation inhibits Reelin and DCX expression and reduces neuroblastoma cell motility and invasiveness." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 23, Issue 12, pp. 4276-87, (2009) (PubMed).
: "The location of DCX mutations predicts malformation severity in X-linked lissencephaly." in: Neurogenetics, Vol. 9, Issue 4, pp. 277-85, (2008) (PubMed).
: "Doublecortin is expressed in articular chondrocytes." in: Biochemical and biophysical research communications, Vol. 363, Issue 3, pp. 694-700, (2007) (PubMed).
: "Induction of neurogenesis in the neocortex of adult mice." in: Nature, Vol. 405, Issue 6789, pp. 951-5, (2000) (PubMed).
: "A novel CNS gene required for neuronal migration and involved in X-linked subcortical laminar heterotopia and lissencephaly syndrome." in: Cell, Vol. 92, Issue 1, pp. 51-61, (1998) (PubMed).
: "Doublecortin, a brain-specific gene mutated in human X-linked lissencephaly and double cortex syndrome, encodes a putative signaling protein." in: Cell, Vol. 92, Issue 1, pp. 63-72, (1998) (PubMed).
Synonyms and alternative names related to Doublecortin
doublecortin (DCX), doublecortin (Dcx), 18C15.5, DBCN, Dbct, DC, DCX, LISX, SCLH, XLISProtein level used designations for Doublecortin
- doublecortex; lissencephaly, X-linked (doublecortin)
- doublecortin
- doublecortex
- doublin
- lis-X
- lissencephalin-X
- neuronal migration protein doublecortin
- lissencephaly, X-linked (doublecortin)
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