DIS3 抗体
(Exosome Complex Exonuclease RRP44 (DIS3))
Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities (By similarity).
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DIS3 抗体 by 适用
Find DIS3 抗体 for a variety of species such as anti-Human DIS3, anti-Mouse DIS3, anti-Rat DIS3. The species listed below are among those available. Click on a link to go to the corresponding products.
DIS3 抗体 by 应用范围
Find DIS3 抗体 validated for a specific application such as WB, ELISA, IHC, IHC (p). Some of the available applications are listed below. Click on a link to go to the corresponding products.
DIS3 抗体 by 抗体来源
Find DIS3 抗体 with a specific 抗体来源. The 抗体来源 listed below are among those available. Click on a link to go to the corresponding products.
DIS3 抗体 by 克隆形成能力
Find available monoclonal or polyclonal DIS3 抗体. Click on a link to go to the corresponding products.
DIS3 抗体 by 克隆
Find DIS3 抗体 with a specific 克隆. The 克隆 listed below are among those available. Click on a link to go to the corresponding products.
DIS3 抗体 by 标记
Find DIS3 抗体 with a specific conjugate such as FITC, Biotin, HRP. The conjugates listed below are among those available. Click on a link to go to the corresponding products.
Popular DIS3 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (1)
- (2)
Cat. No.
ABIN524835
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (3)
Cat. No.
ABIN524836
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN564954
Quantity
50 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC, IHC (p)
Validations
- (2)
Cat. No.
ABIN1804437
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (1)
Cat. No.
ABIN7152297
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Cow, Human, Mouse, Rabbit, Rat
Application
WB
Validations
- (1)
Cat. No.
ABIN6737950
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (1)
Cat. No.
ABIN6139631
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (2)
Cat. No.
ABIN654155
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC (p), EIA
Validations
- (2)
Cat. No.
ABIN951916
Quantity
0.4 mL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA
Validations
Cat. No.
ABIN7152300
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA
Validations
Cat. No.
ABIN7152298
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat, Zebrafish (Danio rerio)
Application
WB
Validations
Cat. No.
ABIN6751761
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC (p), IF
Validations
Cat. No.
ABIN6991861
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP
Validations
Cat. No.
ABIN7450175
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our DIS3 抗体
: "Global analysis of the nuclear processing of transcripts with unspliced U12-type introns by the exosome." in: Nucleic acids research, Vol. 42, Issue 11, pp. 7358-69, (2014) (PubMed).: "Multiple myeloma-associated hDIS3 mutations cause perturbations in cellular RNA metabolism and suggest hDIS3 PIN domain as a potential drug target." in: Nucleic acids research, Vol. 42, Issue 2, pp. 1270-90, (2014) (PubMed).
: "Mammalian 5'-capped microRNA precursors that generate a single microRNA." in: Cell, Vol. 155, Issue 7, pp. 1568-80, (2013) (PubMed).
: "The fission yeast dis3+ gene encodes a 110-kDa essential protein implicated in mitotic control." in: Molecular and cellular biology, Vol. 11, Issue 12, pp. 5839-47, (1991) (PubMed).
Aliases for DIS3 抗体
DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (DIS3) 抗体DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (Dis3) 抗体
DIS3 exosome endoribonuclease and 3'-5' exoribonuclease (dis3) 抗体
DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (dis3.L) 抗体
2810028N01Rik 抗体
bA555G22.1 抗体
DIS3 抗体
dis3 抗体
dis3p 抗体
EXOSC11 抗体
KIAA1008 抗体
RGD1304646 抗体
RP11-342J4.3 抗体
RRP44 抗体
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