DHX58 抗体
(DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58))
Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1- dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate.
recommended
recommended
recommended
DHX58 抗体 by Grade
Find DHX58 抗体 with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.
DHX58 抗体 by 适用
Find DHX58 抗体 for a variety of species such as anti-Human DHX58, anti-Rat DHX58, anti-Mouse DHX58. The species listed below are among those available. Click on a link to go to the corresponding products.
DHX58 抗体 by 应用范围
Find DHX58 抗体 validated for a specific application such as WB, ELISA, IHC, FACS. Some of the available applications are listed below. Click on a link to go to the corresponding products.
DHX58 抗体 by 抗体来源
Find DHX58 抗体 with a specific 抗体来源. The 抗体来源 listed below are among those available. Click on a link to go to the corresponding products.
DHX58 抗体 by 克隆形成能力
Find available monoclonal or polyclonal DHX58 抗体. Click on a link to go to the corresponding products.
DHX58 抗体 by 克隆
Find DHX58 抗体 with a specific 克隆. The 克隆 listed below are among those available. Click on a link to go to the corresponding products.
DHX58 抗体 by 标记
Find DHX58 抗体 with a specific conjugate such as Biotin, APC, FITC. The conjugates listed below are among those available. Click on a link to go to the corresponding products.
Popular DHX58 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, FACS
Validations
- (4)
Cat. No.
ABIN5542450
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, FACS
Validations
- (4)
Cat. No.
ABIN5542451
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7164384
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN263162
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Rat
Application
WB, ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7247327
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP
Validations
- (2)
Cat. No.
ABIN949631
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF, ICC
Validations
- (2)
Cat. No.
ABIN6262957
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (2)
Cat. No.
ABIN6139609
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (1)
Cat. No.
ABIN528898
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Bat, Guinea Pig, Horse, Human, Monkey, Pig
Application
WB
Validations
- (1)
Cat. No.
ABIN6742693
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (2)
Cat. No.
ABIN651621
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA
Validations
Cat. No.
ABIN6390203
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IP
Validations
Cat. No.
ABIN7113458
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA
Validations
Cat. No.
ABIN6990807
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA
Validations
Cat. No.
ABIN6990806
Quantity
0.1 mg
Datasheet
Datasheet
Latest Publications for our DHX58 抗体
: "DDX39B interacts with the pattern recognition receptor pathway to inhibit NF-κB and sensitize to alkylating chemotherapy." in: BMC biology, Vol. 18, Issue 1, pp. 32, (2020) (PubMed).: "Cancer therapies activate RIG-I-like receptor pathway through endogenous non-coding RNAs." in: Oncotarget, Vol. 7, Issue 18, pp. 26496-515, (2018) (PubMed).
: "Comparative analysis of viral RNA signatures on different RIG-I-like receptors." in: eLife, Vol. 5, pp. e11275, (2016) (PubMed).
: "Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 2, pp. 582-7, (2007) (PubMed).
: "Pathogen recognition and innate immunity." in: Cell, Vol. 124, Issue 4, pp. 783-801, (2006) (PubMed).
: "The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 49, pp. 17264-9, (2004) (PubMed).
: "Toll-like receptor control of the adaptive immune responses." in: Nature immunology, Vol. 5, Issue 10, pp. 987-95, (2004) (PubMed).
Aliases for DHX58 抗体
DEXH-box helicase 58 L homeolog (dhx58.L) 抗体DExH-box helicase 58 (DHX58) 抗体
DExH-box helicase 58 (dhx58) 抗体
probable ATP-dependent RNA helicase DHX58 (LOC100566102) 抗体
DEXH (Asp-Glu-X-His) box polypeptide 58 (dhx58) 抗体
DEXH (Asp-Glu-X-His) box polypeptide 58 (Dhx58) 抗体
DEXH-box helicase 58 (Dhx58) 抗体
B430001I08Rik 抗体
D11LGP2 抗体
D11lgp2e 抗体
D11Lgp2e 抗体
DHX58 抗体
lgp2 抗体
LGP2 抗体
Lgp2 抗体
LPG2 抗体
MGC82787 抗体
RGD1310093 抗体
RLR-3 抗体
您还需要查找其他产品吗？
You are here:
