DFFB 抗体
(DNA Fragmentation Factor, 40kDa, beta Polypeptide (Caspase-Activated DNase) (DFFB))
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of these variants has not been determined. [provided by RefSeq, Jul 2008].
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DFFB 抗体 by 适用
Find DFFB 抗体 for a variety of species such as anti-Human DFFB, anti-Mouse DFFB, anti-Rat DFFB. The species listed below are among those available. Click on a link to go to the corresponding products.
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Find DFFB 抗体 validated for a specific application such as WB, ELISA, IF (cc), IF (p). Some of the available applications are listed below. Click on a link to go to the corresponding products.
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Find available monoclonal or polyclonal DFFB 抗体. Click on a link to go to the corresponding products.
DFFB 抗体 by 克隆
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Popular DFFB 抗体
Product
Reactivity
Application
Validations
Cat. No.
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Datasheet
Reactivity
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Application
ELISA, IHC, FACS
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Cat. No.
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Quantity
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Application
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Cat. No.
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Cat. No.
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Cat. No.
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Quantity
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Application
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Cat. No.
ABIN514957
Quantity
100 μg
Datasheet
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Application
WB, IHC, IHC (p)
Validations
- (2)
Cat. No.
ABIN307617
Quantity
0.1 mg
Datasheet
Datasheet
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Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
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Cat. No.
ABIN724085
Quantity
100 μL
Datasheet
Datasheet
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ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
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Cat. No.
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Cat. No.
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Cat. No.
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0.1 mg
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Datasheet
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Cat. No.
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Quantity
0.1 mg
Datasheet
Datasheet
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Application
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Cat. No.
ABIN6139552
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB
Validations
- (2)
Cat. No.
ABIN189883
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
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Application
WB, IF, EIA
Validations
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Cat. No.
ABIN499738
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
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Application
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Validations
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Cat. No.
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Quantity
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Datasheet
Datasheet
Latest Publications for our DFFB 抗体
: "Caspase-dependent cell death-associated release of nucleosome and damage-associated molecular patterns." in: Cell death & disease, Vol. 5, pp. e1494, (2014) (PubMed).: "Antitumor and chemosensitizing action of dichloroacetate implicates modulation of tumor microenvironment: a role of reorganized glucose metabolism, cell survival regulation and macrophage ..." in: Toxicology and applied pharmacology, Vol. 273, Issue 1, pp. 196-208, (2013) (PubMed).
: "DNA degradation in development and programmed cell death." in: Annual review of immunology, Vol. 23, pp. 853-75, (2005) (PubMed).
: "Large complex formation of the inhibitor of caspase-activated DNase." in: Apoptosis : an international journal on programmed cell death, Vol. 10, Issue 3, pp. 651-6, (2005) (PubMed).
: "Degradation of chromosomal DNA during apoptosis." in: Cell death and differentiation, Vol. 10, Issue 1, pp. 108-16, (2003) (PubMed).
: "Human apurinic/apyrimidinic endonuclease (Ape1) and its N-terminal truncated form (AN34) are involved in DNA fragmentation during apoptosis." in: The Journal of biological chemistry, Vol. 278, Issue 39, pp. 37768-76, (2003) (PubMed).
: "The DFF40/CAD endonuclease and its role in apoptosis." in: Acta biochimica Polonica, Vol. 47, Issue 4, pp. 1037-44, (2002) (PubMed).
: "Activation of the apoptotic endonuclease DFF40 (caspase-activated DNase or nuclease). Oligomerization and direct interaction with histone H1." in: The Journal of biological chemistry, Vol. 274, Issue 20, pp. 13836-40, (1999) (PubMed).
: "A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD." in: Nature, Vol. 391, Issue 6662, pp. 43-50, (1998) (PubMed).
: "The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 15, pp. 8461-6, (1998) (PubMed).
Aliases for DFFB 抗体
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (CAD) 抗体DNA fragmentation factor subunit beta (DFFB) 抗体
DNA fragmentation factor, beta polypeptide (caspase-activated DNase) (dffb) 抗体
DNA fragmentation factor subunit beta (LOC100223514) 抗体
DNA fragmentation factor, beta subunit (Dffb) 抗体
DNA fragmentation factor subunit beta (Dffb) 抗体
40kDa 抗体
5730477D02Rik 抗体
CAD 抗体
Cad 抗体
CPAN 抗体
DFF-40 抗体
DFF2 抗体
DFF40 抗体
Didff 抗体
LOC100223514 抗体
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