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DFFB 产品

(DNA Fragmentation Factor, 40kDa, beta Polypeptide (Caspase-Activated DNase) (DFFB))
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of these variants has not been determined. [provided by RefSeq, Jul 2008].

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Featured DFFB Categories

DFFB 抗体

High quality antibodies with extensive validation data.

DFFB ELISA试剂盒

Reliable ELISA kits for a wide range of species.

DFFB 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended DFFB 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, IHC, FACS
Validations
  • (4)
Cat. No. ABIN7193449
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, FACS, IHC (p)
Validations
  • (4)
Cat. No. ABIN653798
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7150177
Quantity 100 μL
Datasheet Datasheet

Recommended DFFB ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6955422
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN1114002
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN1114001
Quantity 96 tests
Datasheet Datasheet

Recommended DFFB 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1351482
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1351481
Quantity 25 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7393079
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our DFFB Products

Yoon, Park, Han, Kang, Kim, Lee, Park, Shin, Kim, Yun, Chwae: "Caspase-dependent cell death-associated release of nucleosome and damage-associated molecular patterns." in: Cell death & disease, Vol. 5, pp. e1494, (2014) (PubMed).

Kumar, Kant, Singh et al.: "Antitumor and chemosensitizing action of dichloroacetate implicates modulation of tumor microenvironment: a role of reorganized glucose metabolism, cell survival regulation and macrophage ..." in: Toxicology and applied pharmacology, Vol. 273, Issue 1, pp. 196-208, (2013) (PubMed).

Nagata: "DNA degradation in development and programmed cell death." in: Annual review of immunology, Vol. 23, pp. 853-75, (2005) (PubMed).

Kanouchi, Nishizaki, Minatogawa, Toné: "Large complex formation of the inhibitor of caspase-activated DNase." in: Apoptosis : an international journal on programmed cell death, Vol. 10, Issue 3, pp. 651-6, (2005) (PubMed).

Nagata, Nagase, Kawane, Mukae, Fukuyama: "Degradation of chromosomal DNA during apoptosis." in: Cell death and differentiation, Vol. 10, Issue 1, pp. 108-16, (2003) (PubMed).

Yoshida, Urasaki, Waltham, Bergman, Pourquier, Rothwell, Inuzuka, Weinstein, Ueda, Appella, Hickson, Pommier: "Human apurinic/apyrimidinic endonuclease (Ape1) and its N-terminal truncated form (AN34) are involved in DNA fragmentation during apoptosis." in: The Journal of biological chemistry, Vol. 278, Issue 39, pp. 37768-76, (2003) (PubMed).

Wid?ak: "The DFF40/CAD endonuclease and its role in apoptosis." in: Acta biochimica Polonica, Vol. 47, Issue 4, pp. 1037-44, (2002) (PubMed).

Liu, Zou, Widlak, Garrard, Wang: "Activation of the apoptotic endonuclease DFF40 (caspase-activated DNase or nuclease). Oligomerization and direct interaction with histone H1." in: The Journal of biological chemistry, Vol. 274, Issue 20, pp. 13836-40, (1999) (PubMed).

Enari, Sakahira, Yokoyama, Okawa, Iwamatsu, Nagata: "A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD." in: Nature, Vol. 391, Issue 6662, pp. 43-50, (1998) (PubMed).

Liu, Li, Widlak, Zou, Luo, Garrard, Wang: "The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 15, pp. 8461-6, (1998) (PubMed).

Synonyms and alternative names related to DFFB

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (CAD), DNA fragmentation factor subunit beta (DFFB), DNA fragmentation factor, beta polypeptide (caspase-activated DNase) (dffb), DNA fragmentation factor subunit beta (LOC100223514), DNA fragmentation factor, beta subunit (Dffb), DNA fragmentation factor subunit beta (Dffb), 40kDa, 5730477D02Rik, CAD, Cad, CPAN, DFF-40, DFF2, DFF40, Didff, LOC100223514

Protein level used designations for DFFB

  • CAD protein
  • CAD trifunctional protein
  • multifunctional protein CAD
  • DNA fragmentation factor 40 kDa subunit
  • DNA fragmentation factor subunit beta
  • caspase-activated DNase
  • caspase-activated deoxyribonuclease
  • caspase-activated nuclease
  • DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
  • DNA fragmentation factor, 40 kD, beta polypeptide
  • DFF-40
  • DNA fragmentation factor, 40 kD, beta subunit
  • DNase inhibited by DNA fragmentation factor
  • DNA fragmentation factor 40 kD beta polypeptide (caspase-activated DNase)
  • DNA fragmentation factor, 40 kD, beta polypeptide (caspase-activated DNase)
  • DNA fragmentation factor, beta polypeptide (caspase-activated DNase)
  • DNA fragmentation factor, beta subunit
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