DFFA 产品
(DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA))
Categories
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured DFFA Categories
DFFA 抗体
High quality antibodies with extensive validation data.
DFFA ELISA试剂盒
Reliable ELISA kits for a wide range of species.
DFFA 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended DFFA 抗体
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Cat. No.
ABIN514954
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100 μL
Datasheet
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Cat. No.
ABIN7150176
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Cat. No.
ABIN7442849
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Recommended DFFA ELISA试剂盒
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ABIN6384470
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Recommended DFFA 蛋白
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ABIN7122682
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Cat. No.
ABIN1351477
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Latest Publications for our DFFA Products
: "Inhibition of TRAIL-induced apoptosis by Bcl-2 overexpression." in: Oncogene, Vol. 21, Issue 15, pp. 2283-94, (2002) (PubMed).: "Arsenic trioxide promotes histone H3 phosphoacetylation at the chromatin of CASPASE-10 in acute promyelocytic leukemia cells." in: The Journal of biological chemistry, Vol. 277, Issue 51, pp. 49504-10, (2002) (PubMed).
: "Solution structure of the DFF-C domain of DFF45/ICAD. A structural basis for the regulation of apoptotic DNA fragmentation." in: Journal of molecular biology, Vol. 321, Issue 2, pp. 317-27, (2002) (PubMed).
: "Growth phase-dependent expression of ICAD-L/DFF45 modulates the pattern of apoptosis in human colonic cancer cells." in: Cancer research, Vol. 62, Issue 7, pp. 2169-74, (2002) (PubMed).
: "The regulation of DNAse activities in subcellular compartments of activated thymocytes." in: Immunology, Vol. 105, Issue 4, pp. 399-406, (2002) (PubMed).
: "Roles of DNA fragmentation factor and poly(ADP-ribose) polymerase in an amplification phase of tumor necrosis factor-induced apoptosis." in: The Journal of biological chemistry, Vol. 276, Issue 41, pp. 38185-92, (2001) (PubMed).
: "Functional differences of two forms of the inhibitor of caspase-activated DNase, ICAD-L, and ICAD-S." in: The Journal of biological chemistry, Vol. 274, Issue 22, pp. 15740-4, (1999) (PubMed).
: "Functional interaction of DFF35 and DFF45 with caspase-activated DNA fragmentation nuclease DFF40." in: The Journal of biological chemistry, Vol. 274, Issue 30, pp. 20759-62, (1999) (PubMed).
: "A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD." in: Nature, Vol. 391, Issue 6662, pp. 43-50, (1998) (PubMed).
: "Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis." in: Nature, Vol. 391, Issue 6662, pp. 96-9, (1998) (PubMed).
Synonyms and alternative names related to DFFA
DNA fragmentation factor subunit alpha (DFFA), DNA fragmentation factor, alpha subunit (Dffa), DNA fragmentation factor, 45kDa, alpha polypeptide (dffa), DNA fragmentation factor subunit alpha (Dffa), DNA fragmentation factor, alpha polypeptide (dffa), A330085O09Rik, DFF-45, DFF1, DFF35, Dff45, DFFA, ICAD, ICAD-L, ICAD-S, zgc:92229Protein level used designations for DFFA
- DFF45
- DNA fragmentation factor 45 kDa subunit
- DNA fragmentation factor subunit alpha
- inhibitor of CAD
- DFF-45
- DNA fragmentation factor, 45kDa, alpha polypeptide
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