DCLK2 产品
(Doublecortin-Like Kinase 2 (DCLK2))
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This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Sep 2010].
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Featured DCLK2 Categories
Recommended DCLK2 抗体
Product
Reactivity
Application
Validations
Cat. No.
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Datasheet
Reactivity
Human, Mouse
Application
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Cat. No.
ABIN6258107
Quantity
100 μL
Datasheet
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- (1)
Cat. No.
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Recommended DCLK2 ELISA试剂盒
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Reactivity
Analytical Method
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Reactivity
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Analytical Method
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Cat. No.
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Recommended DCLK2 蛋白
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Reactivity
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Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7421590
Quantity
100 μg
Datasheet
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Reactivity
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Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7423801
Quantity
100 μg
Datasheet
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Latest Publications for our DCLK2 Products
: "The doublecortin gene family and disorders of neuronal structure." in: Central nervous system agents in medicinal chemistry, Vol. 10, Issue 1, pp. 32-46, (2010) (PubMed).: "Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizures." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 16, pp. 6766-71, (2009) (PubMed).
: "Gene trapping: an antibody-dependent approach for verifying integration in your favorite gene." in: Cellular & molecular biology letters, Vol. 13, Issue 4, pp. 614-20, (2008) (PubMed).
: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, (2002) (PubMed).
Synonyms and alternative names related to DCLK2
doublecortin like kinase 2 (DCLK2), doublecortin-like kinase 2 (Dclk2), doublecortin-like kinase 2a (dclk2a), 6330415M09Rik, AU044875, cb572, CL2, CLICK-II, Click-II, CLICK2, CLIK2, DCAMKL2, Dcamkl2, DCDC3, DCDC3B, DCK2, Dck2, dclk, DCLK2, RGD1308384, sb:cb572, si:dkey-180n16.1Protein level used designations for DCLK2
- CaMK-like CREB regulatory kinase 2
- doublecortin and CaM kinase-like 2
- doublecortin domain-containing protein 3B
- doublecortin-like and CAM kinase-like 2
- serine/threonine-protein kinase DCLK2
- caMK-like CREB regulatory kinase 2
- doublecortin-like kinase 2
- zDCLK
- doublecortin kinase 2
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