DCLK1 抗体
(Doublecortin-Like Kinase 1 (DCLK1))
This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010].
recommended
DCLK1 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
recommended
recommended
DCLK1 抗体 by 适用
Find DCLK1 抗体 for a variety of species such as anti-Human DCLK1, anti-Mouse DCLK1, anti-Rat DCLK1. The species listed below are among those available. Click on a link to go to the corresponding products.
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Popular DCLK1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, ICC, IHC (p), IHC (fro)
Validations
- (6)
Cat. No.
ABIN7436015
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (5)
Cat. No.
ABIN563973
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB
Validations
- (15)
- (3)
Cat. No.
ABIN391324
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (3)
Cat. No.
ABIN7169039
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ICC, IP
Validations
- (2)
Cat. No.
ABIN7427147
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (2)
Cat. No.
ABIN7101679
Quantity
20 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB
Validations
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Cat. No.
ABIN391323
Quantity
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Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB
Validations
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Cat. No.
ABIN6243151
Quantity
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Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
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Cat. No.
ABIN563970
Quantity
50 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
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Cat. No.
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Quantity
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Datasheet
Reactivity
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Application
WB
Validations
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Cat. No.
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Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
WB, ELISA
Validations
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Cat. No.
ABIN3030771
Quantity
0.4 mL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC
Validations
- (2)
Cat. No.
ABIN1031345
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, EIA
Validations
- (2)
Cat. No.
ABIN499716
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC (p), EIA
Validations
- (2)
Cat. No.
ABIN359414
Quantity
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Datasheet
Datasheet
Latest Publications for our DCLK1 抗体
: "Enhancement of cytotoxic effects of gemcitabine by Dclk1 inhibition through suppression of Chk1 phosphorylation in human pancreatic cancer cells." in: Oncology reports, Vol. 38, Issue 5, pp. 3238-3244, (2018) (PubMed).: "Catecholamines Facilitate Fuel Expenditure and Protect Against Obesity via a Novel Network of the Gut-Brain Axis in Transcription Factor Skn-1-deficient Mice." in: EBioMedicine, Vol. 8, pp. 60-71, (2017) (PubMed).
: "DCLK1 is up-regulated and associated with metastasis and prognosis in colorectal cancer." in: Journal of cancer research and clinical oncology, Vol. 142, Issue 10, pp. 2131-40, (2017) (PubMed).
: "Doublecortin-like kinase 1-positive enterocyte - a new cell type in human intestine." in: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, Vol. 124, Issue 11, pp. 958-965, (2017) (PubMed).
: "Goblet Cell Ratio in Combination with Differentiation and Stem Cell Markers in Barrett Esophagus Allow Distinction of Patients with and without Esophageal Adenocarcinoma." in: Cancer prevention research (Philadelphia, Pa.), Vol. 10, Issue 1, pp. 55-66, (2017) (PubMed).
: "Data showing proliferation and differentiation of intestinal epithelial cells under targeted depletion of Notch ligands in mouse intestine." in: Data in brief, Vol. 10, pp. 551-556, (2017) (PubMed).
: "Nkx2.2 is expressed in a subset of enteroendocrine cells with expanded lineage potential." in: American journal of physiology. Gastrointestinal and liver physiology, pp. ajpgi.00244.2015, (2015) (PubMed).
: "Distinct expression patterns of Notch ligands, Dll1 and Dll4, in normal and inflamed mice intestine." in: PeerJ, Vol. 2, pp. e370, (2014) (PubMed).
: "Cell lineage identification and stem cell culture in a porcine model for the study of intestinal epithelial regeneration." in: PLoS ONE, Vol. 8, Issue 6, pp. e66465, (2013) (PubMed).
: "Glucagon-like peptide-2 increases dysplasia in rodent models of colon cancer." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 302, Issue 8, pp. G840-9, (2012) (PubMed).
Aliases for DCLK1 抗体
doublecortin like kinase 1 (DCLK1) 抗体doublecortin-like kinase 1a (dclk1a) 抗体
serine/threonine-protein kinase DCLK1 (LOC587664) 抗体
doublecortin-like kinase 2 (dclk2) 抗体
serine/threonine-protein kinase DCLK1 (LOC100539645) 抗体
doublecortin-like kinase 1 (Dclk1) 抗体
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