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DCC 产品

(Deleted in Colorectal Carcinoma (DCC))
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009].

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Featured DCC Categories

DCC 抗体

High quality antibodies with extensive validation data.

DCC ELISA试剂盒

Reliable ELISA kits for a wide range of species.

DCC 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended DCC 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application WB
Validations
  • (4)
Cat. No. ABIN2782671
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IF, ICC
Validations
  • (2)
Cat. No. ABIN6257126
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7242482
Quantity 200 μL
Datasheet Datasheet

Recommended DCC ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6966310
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6730147
Quantity 96 tests
Datasheet Datasheet

Recommended DCC 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7122626
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN7013754
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN7013516
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our DCC Products

Zhang, Mi, Hao, Fan, Gao: "Progesterone down-regulates SLIT/ROBO expression in mouse corpus luteum." in: Acta histochemica, Vol. 119, Issue 7, pp. 740-746, (2017) (PubMed).

Huang, Chu, Hwang, Tsaur: "Coexpression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain." in: The Journal of comparative neurology, Vol. 520, Issue 16, pp. 3650-72, (2012) (PubMed).

Shibata, Reale, Lavin, Silverman, Fearon, Steele, Jessup, Loda, Summerhayes: "The DCC protein and prognosis in colorectal cancer." in: The New England journal of medicine, Vol. 335, Issue 23, pp. 1727-32, (1996) (PubMed).

Reale, Hu, Zafar, Getzenberg, Levine, Fearon: "Expression and alternative splicing of the deleted in colorectal cancer (DCC) gene in normal and malignant tissues." in: Cancer research, Vol. 54, Issue 16, pp. 4493-501, (1994) (PubMed).

Fearon, Cho, Nigro, Kern, Simons, Ruppert, Hamilton, Preisinger, Thomas, Kinzler: "Identification of a chromosome 18q gene that is altered in colorectal cancers." in: Science (New York, N.Y.), Vol. 247, Issue 4938, pp. 49-56, (1990) (PubMed).

Vogelstein, Fearon, Hamilton, Kern, Preisinger, Leppert, Nakamura, White, Smits, Bos: "Genetic alterations during colorectal-tumor development." in: The New England journal of medicine, Vol. 319, Issue 9, pp. 525-32, (1988) (PubMed).

Fearon, Hamilton, Vogelstein: "Clonal analysis of human colorectal tumors." in: Science (New York, N.Y.), Vol. 238, Issue 4824, pp. 193-7, (1987) (PubMed).

Synonyms and alternative names related to DCC

DCC netrin 1 receptor (DCC), DCC netrin 1 receptor (dcc), deleted in colorectal carcinoma (Dcc), deleted in colorectal carcinoma (dcc), DCC netrin 1 receptor (Dcc), netrin receptor DCC (LOC100712666), C030036D22Rik, CRC18, CRCR1, DCC, Dcc, dcca-A, IGDCC1, Igdcc1, MRMV1, xdcc, XDCCa, zdcc

Protein level used designations for DCC

  • colorectal cancer suppressor
  • colorectal tumor suppressor
  • deleted in colorectal cancer protein
  • immunoglobulin superfamily DCC subclass member 1
  • immunoglobulin superfamily, DCC subclass, member 1
  • netrin receptor DCC
  • tumor suppressor protein DCC
  • deleted in colorectal carcinoma
  • deleted in colorectal cancer
  • deleted in colorectal cancer tumor suppressor
  • netrin receptor DCC-like
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