DAZ1 产品
(Deleted in Azoospermia 1 (DAZ1))
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This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications\; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat\; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified\; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains three copies of the 10.8 kb repeat. However, no transcripts containing three copies of the RRM domain have been described\; thus the RefSeq for this gene contains only two RRM domains. [provided by RefSeq, Jul 2008].
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Latest Publications for our DAZ1 Products
: "Do we need to search for gr/gr deletions in infertile men in a clinical setting?" in: Human reproduction (Oxford, England), Vol. 23, Issue 5, pp. 1193-9, (2008) (PubMed).: "Restricted expression of the human DAZ protein in premeiotic germ cells." in: Human reproduction (Oxford, England), Vol. 23, Issue 6, pp. 1280-9, (2008) (PubMed).
: "Quantification of DDX3Y, RBMY1, DAZ and TSPY mRNAs in testes of patients with severe impairment of spermatogenesis." in: Molecular human reproduction, Vol. 13, Issue 10, pp. 705-12, (2007) (PubMed).
: "CD9-regulated adhesion. Anti-CD9 monoclonal antibody induce pre-B cell adhesion to bone marrow fibroblasts through de novo recognition of fibronectin." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 152, Issue 6, pp. 2768-77, (1994) (PubMed).
Synonyms and alternative names related to DAZ1
deleted in azoospermia protein 1 (LOC749905), deleted in azoospermia 1 (DAZ1), DAZ, DAZ1, DAZ4, SPGYProtein level used designations for DAZ1
- deleted in azoospermia 1
- DAZ protein
- deleted in azoospermia 4
- deleted in azoospermia protein 1
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