DAXX 抗体
(Death-Domain Associated Protein (DAXX))
This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008].
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Latest Publications for our DAXX 抗体
: "Necrostatin-1 protects hippocampal neurons against ischemia/reperfusion injury via the RIP3/DAXX signaling pathway in rats." in: Neuroscience letters, Vol. 651, pp. 207-215, (2017) (PubMed).: "Epigenetic dysregulation and poorer prognosis in DAXX-deficient pancreatic neuroendocrine tumours." in: Endocrine-related cancer, Vol. 22, Issue 3, pp. L13-8, (2015) (PubMed).
: "Whole-exome sequencing identifies somatic ATRX mutations in pheochromocytomas and paragangliomas." in: Nature communications, Vol. 6, pp. 6140, (2015) (PubMed).
: "ATRX represses alternative lengthening of telomeres." in: Oncotarget, Vol. 6, Issue 18, pp. 16543-58, (2015) (PubMed).
: "TERT promoter mutations are frequent and show association with MED12 mutations in phyllodes tumors of the breast." in: British journal of cancer, Vol. 113, Issue 8, pp. 1244-8, (2015) (PubMed).
: "Altered PTEN, ATRX, CHGA, CHGB, and TP53 expression are associated with aggressive VHL-associated pancreatic neuroendocrine tumors." in: Hormones & cancer, Vol. 4, Issue 3, pp. 165-75, (2013) (PubMed).
: "Sp100 provides intrinsic immunity against human papillomavirus infection." in: mBio, Vol. 4, Issue 6, pp. e00845-13, (2013) (PubMed).
: "Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. ..." in: Nature, Vol. 482, Issue 7384, pp. 226-31, (2012) (PubMed).
: "Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 25, Issue 7, pp. 1033-9, (2012) (PubMed).
: "Altered telomeres in tumors with ATRX and DAXX mutations. ..." in: Science (New York, N.Y.), Vol. 333, Issue 6041, pp. 425, (2011) (PubMed).
Aliases for DAXX 抗体
death domain associated protein (DAXX) 抗体Fas death domain-associated protein (Daxx) 抗体
28S ribosomal protein S29, mitochondrial (LOC100226911) 抗体
death-domain associated protein (Daxx) 抗体
death domain associated protein (Daxx) 抗体
death-associated protein 6 L homeolog (daxx.L) 抗体
death-domain associated protein (daxx) 抗体
BING2 抗体
DAP6 抗体
daxx 抗体
EAP1 抗体
LOC100226911 抗体
si:dz179b20.7 抗体
wu:fd15c03 抗体
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