DAB2 抗体
(Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2))
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
recommended
recommended
DAB2 适用: 人, 大鼠 WB, ELISA, IF (cc), IF (p), FACS, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
recommended
DAB2 抗体 by 适用
Find DAB2 抗体 for a variety of species such as anti-Human DAB2, anti-Mouse DAB2, anti-Rat DAB2. The species listed below are among those available. Click on a link to go to the corresponding products.
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Find DAB2 抗体 validated for a specific application such as WB, ELISA, IF (cc), IF (p). Some of the available applications are listed below. Click on a link to go to the corresponding products.
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Find available monoclonal or polyclonal DAB2 抗体. Click on a link to go to the corresponding products.
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Popular DAB2 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (4)
Cat. No.
ABIN514859
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human, Rat
Application
WB, ELISA, IF (cc), IF (p), FACS, IHC (p), IHC (fro)
Validations
- (2)
Cat. No.
ABIN760961
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, FACS, IHC (p)
Validations
- (3)
Cat. No.
ABIN652936
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC
Validations
- (1)
Cat. No.
ABIN1386225
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (1)
Cat. No.
ABIN514860
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (1)
Cat. No.
ABIN514861
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IF, ICC
Validations
- (1)
Cat. No.
ABIN6261215
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, FACS, IHC (p)
Validations
- (1)
Cat. No.
ABIN2597796
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB
Validations
- (5)
- (1)
Cat. No.
ABIN1881248
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Human, Mouse, Rabbit, Rat
Application
WB
Validations
- (2)
Cat. No.
ABIN2777076
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Rat
Application
WB, ELISA, IHC (p), IHC (fro)
Validations
Cat. No.
ABIN760963
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, ELISA, IHC (p), IHC (fro)
Validations
Cat. No.
ABIN1388941
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Rat
Application
WB, IF (cc), IF (p), FACS
Validations
Cat. No.
ABIN893369
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Rat
Application
WB, IF (cc), IF (p), FACS
Validations
Cat. No.
ABIN893372
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Rat
Application
WB, IF (cc), IF (p), FACS
Validations
Cat. No.
ABIN893370
Quantity
100 μL
Datasheet
Datasheet
Latest Publications for our DAB2 抗体
: "Alpha-AP-2 directs myosin VI-dependent endocytosis of cystic fibrosis transmembrane conductance regulator chloride channels in the intestine." in: The Journal of biological chemistry, Vol. 285, Issue 22, pp. 17177-87, (2010) (PubMed).: "TGF-beta-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI." in: Nature cell biology, Vol. 12, Issue 3, pp. 286-93, (2010) (PubMed).
: "Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 44, pp. 18722-7, (2009) (PubMed).
: "Cutting edge: Dab2 is a FOXP3 target gene required for regulatory T cell function." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 7, pp. 4192-6, (2009) (PubMed).
: "Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions." in: Oncogene, Vol. 28, Issue 33, pp. 2999-3007, (2009) (PubMed).
: "Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor." in: The EMBO journal, Vol. 21, Issue 18, pp. 4915-26, (2002) (PubMed).
: "The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway." in: The EMBO journal, Vol. 20, Issue 11, pp. 2789-801, (2001) (PubMed).
: "Disabled-2 mediates c-Fos suppression and the cell growth regulatory activity of retinoic acid in embryonic carcinoma cells." in: The Journal of biological chemistry, Vol. 276, Issue 50, pp. 47303-10, (2001) (PubMed).
: "Cloning of a novel phosphoprotein regulated by colony-stimulating factor 1 shares a domain with the Drosophila disabled gene product." in: The Journal of biological chemistry, Vol. 270, Issue 23, pp. 14184-91, (1995) (PubMed).
Aliases for DAB2 抗体
DAB2, clathrin adaptor protein (DAB2) 抗体disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) (dab2) 抗体
Dab, mitogen-responsive phosphoprotein, homolog 2 (dab2) 抗体
DAB2, clathrin adaptor protein (Dab2) 抗体
disabled 2, mitogen-responsive phosphoprotein (Dab2) 抗体
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