CYP2D6 产品
(Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 (CYP2D6))
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This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug\; sparteine and propafenone, both anti-arrythmic drugs\; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population\; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured CYP2D6 Categories
CYP2D6 抗体
High quality antibodies with extensive validation data.
CYP2D6 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
CYP2D6 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CYP2D6 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (5)
Cat. No.
ABIN7437350
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC (p)
Validations
- (5)
Cat. No.
ABIN5518823
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, ICC, IF
Validations
- (3)
Cat. No.
ABIN6258047
Quantity
100 μL
Datasheet
Datasheet
Recommended CYP2D6 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966241
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955249
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955248
Quantity
96 tests
Datasheet
Datasheet
Recommended CYP2D6 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1350974
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Rat
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7407760
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7401203
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our CYP2D6 Products
: "Comparison of Paeoniflorin and Albiflorin on Human CYP3A4 and CYP2D6." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2015, pp. 470219, (2015) (PubMed).: "Production of inhibitory polyclonal antibodies against cytochrome P450s." in: Drug metabolism and pharmacokinetics, Vol. 18, Issue 3, pp. 163-72, (2004) (PubMed).
: "Cytochromes P450: a success story." in: Genome biology, Vol. 1, Issue 6, pp. REVIEWS3003, (2001) (PubMed).
Synonyms and alternative names related to CYP2D6
cytochrome P450 family 2 subfamily D member 6 (CYP2D6), cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6), cytochrome 2D6 (CYP2D6), cytochrome P450, family 2, subfamily D, polypeptide 6 (cyp2d6-b), cytochrome P450 family 2 subfamily D member 6 S homeolog (cyp2d6.S), cytochrome P450 family 2 subfamily D member 6 (cyp2d6), cytochrome P450 2D6 (CYP2D6), cytochrome P450 2D6-like (LOC100988273), CPD6, CYP2D, cyp2d2, CYP2D6, cyp2d6-a, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2D42, CYP2DL1, CYPIID6, MGC64445, P450-DB1, P450C2D, P450DB1Protein level used designations for CYP2D6
- cytochrome P450 2D6
- cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2
- cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2
- cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising), polypeptide 7 pseudogene 2
- cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolising), polypeptide 8 pseudogene 2
- cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6
- cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing)-like 1
- cytochrome P450-DB1
- debrisoquine 4-hydroxylase
- flavoprotein-linked monooxygenase
- microsomal monooxygenase
- xenobiotic monooxygenase
- CYPIID6
- cytochrome P450 CYP2D42
- cytochrome P450, family 2, subfamily D, polypeptide 6
- cytochrome P450 2D6-like
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