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CYP2C8 产品

(Cytochrome P450, Family 2, Subfamily C, Polypeptide 8 (CYP2C8))

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This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010].

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Featured CYP2C8 Categories

CYP2C8 抗体

High quality antibodies with extensive validation data.

CYP2C8 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended CYP2C8 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB
Validations
  • (2)
Cat. No. ABIN514832
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (2)
Cat. No. ABIN947772
Quantity 50 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application ELISA, WB, IHC
Validations
  • (2)
Cat. No. ABIN6258063
Quantity 100 μL
Datasheet Datasheet

Recommended CYP2C8 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6214689
Quantity 96 tests
Datasheet Datasheet

Recommended CYP2C8 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7122581
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1350971
Quantity 25 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3078039
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our CYP2C8 Products

Thomas, Winter, Klumpp, Turpeinen, Klein, Schwab, Zanger: "Peroxisome proliferator-activated receptor alpha, PPARα, directly regulates transcription of cytochrome P450 CYP2C8." in: Frontiers in pharmacology, Vol. 6, pp. 261, (2015) (PubMed).

Leskelä, Jara, Leandro-García, Martínez, García-Donas, Hernando, Hurtado, Vicario, Montero-Conde, Landa, López-Jiménez, Cascón, Milne, Robledo, Rodríguez-Antona: "Polymorphisms in cytochromes P450 2C8 and 3A5 are associated with paclitaxel neurotoxicity." in: The pharmacogenomics journal, Vol. 11, Issue 2, pp. 121-9, (2011) (PubMed).

Pavlov, Ilatovskaya, Levchenko, Mattson, Roman, Staruschenko: "Effects of cytochrome P-450 metabolites of arachidonic acid on the epithelial sodium channel (ENaC)." in: American journal of physiology. Renal physiology, Vol. 301, Issue 3, pp. F672-81, (2011) (PubMed).

Werck-Reichhart, Feyereisen: "Cytochromes P450: a success story." in: Genome biology, Vol. 1, Issue 6, pp. REVIEWS3003, (2001) (PubMed).

Synonyms and alternative names related to CYP2C8

cytochrome P450 family 2 subfamily C member 8 (CYP2C8), Cytochrome P450 2C8 (CTN_0597), cytochrome P450, family 2, subfamily C, polypeptide 8 (CYP2C8), cytochrome P450 family 2 subfamily C member 8 S homeolog (cyp2c8.1.S), cytochrome P450 family 2 subfamily C member 8 (cyp2c8.1), CPC8, cpc8, cyp2c8, CYP2C74, CYPIIC8, cypiic8, MP-12/MP-20, mp-12/mp-20

Protein level used designations for CYP2C8

  • P450 form 1
  • cytochrome P450 2C8
  • cytochrome P450 IIC2
  • cytochrome P450 MP-12
  • cytochrome P450 MP-20
  • cytochrome P450 form 1
  • cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8
  • flavoprotein-linked monooxygenase
  • microsomal monooxygenase
  • s-mephenytoin 4-hydroxylase
  • xenobiotic monooxygenase
  • Cytochrome P450 2C8
  • cytochrome P450 CYP2C74
  • cytochrome P450, family 2, subfamily C, polypeptide 8
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