CTNNA1 抗体
(Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1))
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
recommended
CTNNA1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
recommended
recommended
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CTNNA1 抗体 by 适用
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Latest Publications for our CTNNA1 抗体
: "TALENs-directed knockout of the full-length transcription factor Nrf1α that represses malignant behaviour of human hepatocellular carcinoma (HepG2) cells." in: Scientific reports, Vol. 6, pp. 23775, (2017) (PubMed).: "Loss of alpha-catenin decreases the strength of single E-cadherin bonds between human cancer cells." in: The Journal of biological chemistry, Vol. 284, Issue 27, pp. 18252-9, (2009) (PubMed).
: "Deconstructing the cadherin-catenin-actin complex." in: Cell, Vol. 123, Issue 5, pp. 889-901, (2005) (PubMed).
: "Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly." in: Cell, Vol. 123, Issue 5, pp. 903-15, (2005) (PubMed).
: "Regulation of beta-catenin signaling and maintenance of chondrocyte differentiation by ubiquitin-independent proteasomal degradation of alpha-catenin." in: The Journal of biological chemistry, Vol. 280, Issue 13, pp. 12758-65, (2005) (PubMed).
: "Gastric cancer: new genetic developments." in: Journal of surgical oncology, Vol. 90, Issue 3, pp. 114-33; discussion 133, (2005) (PubMed).
: "Prognostic and clinicopathological features of E-cadherin, alpha-catenin, beta-catenin, gamma-catenin and cyclin D1 expression in human esophageal squamous cell carcinoma." in: World journal of gastroenterology, Vol. 10, Issue 22, pp. 3235-9, (2005) (PubMed).
: "Characterization of cadherin-24, a novel alternatively spliced type II cadherin." in: The Journal of biological chemistry, Vol. 278, Issue 30, pp. 27513-9, (2003) (PubMed).
: "Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 5, pp. 2381-6, (2001) (PubMed).
: "alpha-catenin inhibits beta-catenin signaling by preventing formation of a beta-catenin*T-cell factor*DNA complex." in: The Journal of biological chemistry, Vol. 275, Issue 29, pp. 21883-8, (2000) (PubMed).
Aliases for CTNNA1 抗体
catenin alpha 1 (CTNNA1) 抗体catenin (cadherin associated protein), alpha 1 (Ctnna1) 抗体
catenin alpha 1 (Ctnna1) 抗体
alpha Catenin (alpha-Cat) 抗体
alpha Catenin (Dgri\alpha-Cat) 抗体
catenin alpha-1 (Tsp_10127) 抗体
catenin (cadherin-associated protein), alpha 1 (ctnna1) 抗体
catenin alpha 1 S homeolog (ctnna1.S) 抗体
2010010M04Rik 抗体
a-Cat 抗体
a-cat 抗体
AA517462 抗体
AI988031 抗体
alpha-CAT 抗体
alpha-cat 抗体
Alpha-Cat 抗体
alpha-catenin 抗体
alpha-ctn 抗体
alphaCAT 抗体
alphaCat 抗体
alphacat 抗体
CAP102 抗体
cap102 抗体
Catna1 抗体
catna1 抗体
CG17947 抗体
CT39986 抗体
ctnna 抗体
ctnna1 抗体
Dalpha-Cat 抗体
Dalpha-cat 抗体
DalphaC 抗体
Dalphacat 抗体
DgriGH19548 抗体
dgri_GLEANR_3829 抗体
Dmcatp 抗体
Dmel\\CG17947 抗体
GH19548 抗体
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