CTCF 产品
(CCCTC-Binding Factor (Zinc Finger Protein) (CTCF))
Categories
This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].
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Featured CTCF Categories
CTCF 抗体
High quality antibodies with extensive validation data.
CTCF ELISA试剂盒
Reliable ELISA kits for a wide range of species.
CTCF 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CTCF 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF, ChIP, IP
Validations
- (6)
Cat. No.
ABIN3021507
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ChIP-seq, CUT&RUN
Validations
- (2)
- (1)
Cat. No.
ABIN6731034
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Monkey, Mouse, Rat
Application
IHC, IF
Validations
- (5)
Cat. No.
ABIN7255588
Quantity
200 μL
Datasheet
Datasheet
Recommended CTCF ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6965536
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Chicken
Analytical Method
Validations
Cat. No.
ABIN1162630
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6213282
Quantity
96 tests
Datasheet
Datasheet
Recommended CTCF 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1350630
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (3)
- (1)
Cat. No.
ABIN1350629
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122187
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our CTCF Products
: "DNA methylation profiling in human Huntington's disease brain." in: Human molecular genetics, Vol. 25, Issue 10, pp. 2013-2030, (2016) (PubMed).: "The Human GATA1 Gene Retains a 5' Insulator That Maintains Chromosomal Architecture and GATA1 Expression Levels in Splenic Erythroblasts." in: Molecular and cellular biology, Vol. 35, Issue 10, pp. 1825-37, (2015) (PubMed).
: "Domain-Specific and Stage-Intrinsic Changes in Tcrb Conformation during Thymocyte Development." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 195, Issue 3, pp. 1262-72, (2015) (PubMed).
: "CTCF binding to the first intron of the major immediate early (MIE) gene of human cytomegalovirus (HCMV) negatively regulates MIE gene expression and HCMV replication." in: Journal of virology, Vol. 88, Issue 13, pp. 7389-401, (2014) (PubMed).
: "Epigenetic control of SPI1 gene by CTCF and ISWI ATPase SMARCA5." in: PLoS ONE, Vol. 9, Issue 2, pp. e87448, (2014) (PubMed).
: "Friedreich ataxia patient tissues exhibit increased 5-hydroxymethylcytosine modification and decreased CTCF binding at the FXN locus." in: PLoS ONE, Vol. 8, Issue 9, pp. e74956, (2013) (PubMed).
: "Identification of CTCF as a master regulator of the clustered protocadherin genes." in: Nucleic acids research, Vol. 40, Issue 8, pp. 3378-91, (2012) (PubMed).
: "CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing." in: Nature, Vol. 479, Issue 7371, pp. 74-9, (2011) (PubMed).
: "DNA methylation prevents CTCF-mediated silencing of the oncogene BCL6 in B cell lymphomas." in: The Journal of experimental medicine, Vol. 207, Issue 9, pp. 1939-50, (2010) (PubMed).
: "Loss of imprinting of IGF2 and H19, loss of heterozygosity of IGF2R and CTCF, and Helicobacter pylori infection in laryngeal squamous cell carcinoma." in: Journal of molecular medicine (Berlin, Germany), Vol. 86, Issue 9, pp. 1057-66, (2008) (PubMed).
Synonyms and alternative names related to CTCF
CCCTC-binding factor (CTCF), CCCTC-binding factor (zinc finger protein) (ctcf), CCCTC-binding factor (ctcf), CCCTC-binding factor (Ctcf), AW108038, CTCF, im:7152666, xctcfProtein level used designations for CTCF
- transcriptional repressor CTCF
- CCCTC-binding factor (zinc finger protein)
- transcriptional repressor CTCF-like
- 11-zinc finger protein
- CTCFL paralog
- 11 zinc finger transcriptional repressor
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