CRBN 产品
(Cereblon (CRBN))
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This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].
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CRBN 抗体
High quality antibodies with extensive validation data.
CRBN ELISA试剂盒
Reliable ELISA kits for a wide range of species.
CRBN 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
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Latest Publications for our CRBN Products
: "Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome." in: eLife, Vol. 7, (2019) (PubMed).: "Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs." in: Bioorganic & medicinal chemistry, Vol. 27, Issue 12, pp. 2466-2479, (2019) (PubMed).
: "Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations." in: Nature communications, Vol. 10, Issue 1, pp. 3468, (2019) (PubMed).
: "Iterative design and optimization of initially inactive Proteolysis Targeting Chimeras (PROTACs) identify VZ185 as a potent, fast and selective von Hippel-Lindau (VHL)-based dual degrader probe of ..." in: Journal of medicinal chemistry, (2018) (PubMed).
: "Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation." in: Nature chemical biology, Vol. 14, Issue 2, pp. 163-170, (2018) (PubMed).
: "Lenalidomide Stabilizes the Erythropoietin Receptor by Inhibiting the E3 Ubiquitin Ligase RNF41." in: Cancer research, Vol. 76, Issue 12, pp. 3531-40, (2016) (PubMed).
: "Deficient import of acetyl-CoA into the ER lumen causes neurodegeneration and propensity to infections, inflammation, and cancer." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 20, pp. 6772-89, (2014) (PubMed).
: "CRL4A(CRBN) E3 ubiquitin ligase restricts BK channel activity and prevents epileptogenesis." in: Nature communications, Vol. 5, pp. 3924, (2014) (PubMed).
: "Measuring cereblon as a biomarker of response or resistance to lenalidomide and pomalidomide requires use of standardized reagents and understanding of gene complexity." in: British journal of haematology, Vol. 164, Issue 2, pp. 233-44, (2014) (PubMed).
: "Identification of salt-inducible kinase 3 as a novel tumor antigen associated with tumorigenesis of ovarian cancer." in: Oncogene, Vol. 30, Issue 33, pp. 3570-84, (2011) (PubMed).
Synonyms and alternative names related to CRBN
cereblon (crbn), cereblon (CRBN), ATP-dependent protease La (LON) domain protein (AT2G25740), cereblon (Crbn), 2610203G15Rik, 2900045O07Rik, AF229032, AW108261, F3N11.21, MRT2, mrt2a, MRT2A, piL, zgc:92404Protein level used designations for CRBN
- protein cereblon
- zcrbn
- cereblon
- protein cereblon-like
- protein x 0001
- novel lethal
- protein PiL
- Protein cereblon
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