CPSF4 产品
(Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4))
Categories
Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
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Recommended CPSF4 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7147920
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IHC (fro), IHC (p)
Validations
- (2)
Cat. No.
ABIN1386751
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC
Validations
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Cat. No.
ABIN6261007
Quantity
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Datasheet
Datasheet
Recommended CPSF4 蛋白
Latest Publications for our CPSF4 Products
: "Alanine substitutions within a linker region of the influenza A virus non-structural protein 1 alter its subcellular localization and attenuate virus replication." in: The Journal of general virology, Vol. 92, Issue Pt 8, pp. 1832-42, (2011) (PubMed).Synonyms and alternative names related to CPSF4
cleavage and polyadenylation specific factor 4 (CPSF4), cleavage and polyadenylation specific factor 4, 30kDa (Cpsf4), cleavage and polyadenylation specific factor 4 (LOC733099), cleavage and polyadenylation specific factor 4 (LOC100360200), cleavage and polyadenylation specific factor 4 S homeolog (cpsf4.S), cleavage and polyadenylation specific factor 4 (cpsf4), cleavage and polyadenylation specific factor 4 (Cpsf4), 30kDa, C79664, cpsf30, CPSF30, nar, NAR, neb1, NEB1Protein level used designations for CPSF4
- no arches
- GLEAN_10339
- cleavage and polyadenylation specific factor 4
- cleavage and polyadenylation specificity factor subunit 4
- cleavage and polyadenylation specific factor 4, 30kDa
- CPSF 30 kDa subunit
- cleavage and polyadenylation specific factor 4, 30kD subunit
- cleavage and polyadenylation specificity factor 30 kDa subunit
- clipper homolog
- clipper/CPSF 30K
- musculus clipper/cleavage and polyadenylation specificity factor 30 kDa subunit
- NS1 effector domain-binding protein 1
- cleavage-polyadenylation specificity factor, 30kD
- neb-1
- no arches homolog
- no arches-like zinc finger protein
- cleavage-polyadenylation specificity factor, 30 kD
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