(Cytochrome C Oxidase Subunit VIa Polypeptide 2 (COX6A2))
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Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (heart/muscle isoform) of subunit VIa, and polypeptide 2 is present only in striated muscles. Polypeptide 1 (liver isoform) of subunit VIa is encoded by a different gene, and is found in all non-muscle tissues. These two polypeptides share 66% amino acid sequence identity. [provided by RefSeq, Jul 2008].
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Boczonadi, Giunta, Lane, Tulinius, Schara, Horvath: "Investigating the role of the physiological isoform switch of cytochrome c oxidase subunits in reversible mitochondrial disease." in: The international journal of biochemistry & cell biology, (2015) (PubMed).
Synonyms and alternative names related to COX6A2
cytochrome c oxidase subunit 6A2 (COX6A2), cytochrome c oxidase subunit VIa polypeptide 2 (Cox6a2), cytochrome c oxidase subunit 6A2 (Cox6a2), cytochrome c oxidase subunit VIa polypeptide 2 (COX6A2), COX6AH, COXVIAH, CoxVIaH, VIaH
Protein level used designations for COX6A2
COX VIa-M
cytochrome c oxidase polypeptide VIa-heart
cytochrome c oxidase subunit 6A2, mitochondrial
cytochrome c oxidase subunit VIA-muscle
subunit VIaH (heart-type)
COXVIAH
cytochrome c oxidase subunit VIa polypeptide 2 (heart)
cytochrome c oxidase polypeptide VIb
Cytochrome c oxidase polypeptide VIa-heart, mitochondrial