COPS5 产品
(COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5))
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The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008].
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Featured COPS5 Categories
COPS5 抗体
High quality antibodies with extensive validation data.
COPS5 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
COPS5 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended COPS5 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF, ChIP
Validations
- (7)
Cat. No.
ABIN7266497
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (4)
Cat. No.
ABIN3022512
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (4)
Cat. No.
ABIN6138883
Quantity
100 μL
Datasheet
Datasheet
Recommended COPS5 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1381254
Quantity
96 tests
Datasheet
Datasheet
Recommended COPS5 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1350059
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN2712494
Quantity
20 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
Cat. No.
ABIN7447863
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our COPS5 Products
: "Nedd8 hydrolysis by UCH proteases in Plasmodium parasites." in: PLoS pathogens, Vol. 15, Issue 10, pp. e1008086, (2019) (PubMed).: "COPS5 protein overexpression increases amyloid plaque burden, decreases spinophilin-immunoreactive puncta, and exacerbates learning and memory deficits in the mouse brain." in: The Journal of biological chemistry, Vol. 290, Issue 14, pp. 9299-309, (2015) (PubMed).
: "Redox signalling to nuclear regulatory proteins by reactive oxygen species contributes to oestrogen-induced growth of breast cancer cells." in: British journal of cancer, Vol. 112, Issue 10, pp. 1687-702, (2015) (PubMed).
: "COPS5 (Jab1) protein increases ? site processing of amyloid precursor protein and amyloid ? peptide generation by stabilizing RanBP9 protein levels." in: The Journal of biological chemistry, Vol. 288, Issue 37, pp. 26668-77, (2013) (PubMed).
: "The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF)." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 34, pp. E577-85, (2011) (PubMed).
: "In utero exposure to dioxin causes neocortical dysgenesis through the actions of p27Kip1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 37, pp. 16331-5, (2010) (PubMed).
: "Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development." in: Molecular and cellular biology, Vol. 28, Issue 18, pp. 5621-33, (2008) (PubMed).
: "The subunit CSN6 of the COP9 signalosome is cleaved during apoptosis." in: The Journal of biological chemistry, Vol. 282, Issue 17, pp. 12557-65, (2007) (PubMed).
: "Binding of JAB1/CSN5 to MIF is mediated by the MPN domain but is independent of the JAMM motif." in: FEBS letters, Vol. 579, Issue 7, pp. 1693-701, (2005) (PubMed).
: "Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase." in: Nature cell biology, Vol. 6, Issue 12, pp. 1229-35, (2004) (PubMed).
Synonyms and alternative names related to COPS5
COP9 signalosome subunit 5 (CSN5), COP9 signalosome subunit 5 (COPS5), COP9 signalosome subunit 5 (cops5), COP9 signalosome complex subunit 5 (CpipJ_CPIJ012314), COP9 signalosome complex subunit 5 (Bm1_46585), COP9 signalosome complex subunit 5 (VDBG_06932), COP9 signalosome complex subunit 5 (LOAG_01443), COP9 signalosome complex subunit 5 (csn5), COP9 signalosome subunit 5 (Cops5), COP9 signalosome subunit 5 S homeolog (cops5.S), COP9 signalosome complex subunit 5 (csn-5), AI303502, BcDNA.LD14392, BcDNA:LD14392, CG14884, CH5, COPS5, CSN-5, Csn5, csn5, CSN5, DCH5, Dch5, dch5, Dmel\\CG14884, JAB1, Jab1, JAB1/CSN5, jab1/csn5, JadBp, l(3)89Cf, l(3)L4032, l(3)M203, MGC76063, MOV-34, Mov34, quo, Sgn5, SGN5, zgc:73130Protein level used designations for COPS5
- CG14884-PA
- CG14884-PB
- COP9 complex subunit 5
- CSN5-PA
- CSN5-PB
- JUN activation domain-binding protein-1
- Jun activation domain binding protein
- drosophila COP9 signalosome homolog 5
- COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)
- COP9 signalosome complex subunit 5
- signalosome subunit 5
- COP9 signalosome subunit 5
- COP9 signalosome complex subunit 5-like
- COP9 complex S5
- Jun activation domain-binding protein 1
- Jun coactivator
- Kip1 C-terminus-interacting protein 2
- COP9 constitutive photomorphogenic-like subunit 5
- c-Jun activation domain binding protein-1
- 38 kDa Mov34 homolog
- COP9 constitutive photomorphogenic homolog subunit 5
- jun activation domain-binding protein 1
- COP9 (constitutive photomorphogenic) homolog, subunit 5
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