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COL4a3 产品

(Collagen, Type IV, alpha 3 (COL4A3))
Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jun 2010].

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Featured COL4a3 Categories

COL4a3 抗体

High quality antibodies with extensive validation data.

COL4a3 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

COL4a3 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended COL4a3 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (4)
Cat. No. ABIN7434707
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse, Rat
Application ELISA, WB, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
  • (2)
  • (2)
Cat. No. ABIN678128
Quantity 100 μL
Datasheet Datasheet
Reactivity Horse, Human, Mouse
Application WB
Validations
  • (1)
  • (1)
Cat. No. ABIN6746738
Quantity 100 μL
Datasheet Datasheet

Recommended COL4a3 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6954946
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN5653131
Quantity 96 tests
Datasheet Datasheet

Recommended COL4a3 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Rat
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN7321080
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7395947
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN5709311
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our COL4a3 Products

Sun, Liu, Pei, Yao, Ma, Mu, Wang, Zhang, Yang, Wang, Xue, Zhai, Carare, Qin, Yan: "The impairment of intramural periarterial drainage in brain after subarachnoid hemorrhage." in: Acta neuropathologica communications, Vol. 10, Issue 1, pp. 187, (2022) (PubMed).

Yasuda, Fukui, Okada, Yamawaki: "T3 peptide, a fragment of tumstatin, stimulates proliferation and migration of cardiac fibroblasts through activation of Akt signaling pathway." in: Naunyn-Schmiedeberg's archives of pharmacology, Vol. 390, Issue 11, pp. 1135-1144, (2017) (PubMed).

Jeruschke, Jeruschke, DiStasio, Karaterzi, Büscher, Nalbant, Klein-Hitpass, Hoyer, Weiss, Stottmann, Weber: "Everolimus Stabilizes Podocyte Microtubules via Enhancing TUBB2B and DCDC2 Expression." in: PLoS ONE, Vol. 10, Issue 9, pp. e0137043, (2015) (PubMed).

Faiz, Tjin, Harkness, Weckmann, Bao, Black, Oliver, Burgess: "The expression and activity of cathepsins D, H and K in asthmatic airways." in: PLoS ONE, Vol. 8, Issue 3, pp. e57245, (2013) (PubMed).

Thevenard, Ramont, Mir, Dupont-Deshorgue, Maquart, Monboisse, Brassart-Pasco: "A new anti-tumor strategy based on in vivo tumstatin overexpression after plasmid electrotransfer in muscle." in: Biochemical and biophysical research communications, Vol. 432, Issue 4, pp. 549-52, (2013) (PubMed).

Jones, Wang, Dookie, Griffin: "The role of TG2 in ECV304-related vasculogenic mimicry." in: Amino acids, Vol. 44, Issue 1, pp. 89-101, (2013) (PubMed).

Tan, ONeill, Naciri, Dowling, Al-Rubeai: "Cellular and transcriptomic analysis of human mesenchymal stem cell response to plasma-activated hydroxyapatite coating." in: Acta biomaterialia, Vol. 8, Issue 4, pp. 1627-38, (2012) (PubMed).

Arcaro, Volinia, Zvelebil, Stein, Watton, Layton, Gout, Ahmadi, Downward, Waterfield: "Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity." in: The Journal of biological chemistry, Vol. 273, Issue 49, pp. 33082-90, (1999) (PubMed).

Synonyms and alternative names related to COL4a3

collagen type IV alpha 3 chain (COL4A3), collagen, type IV, alpha 3 (col4a3), collagen, type IV, alpha 3 (Col4a3), collagen type IV alpha 3 chain (Col4a3), alpha3(IV), zTumstatin, [a]3(IV)

Protein level used designations for COL4a3

  • type IV collagen alpha 3 chain
  • collagen alpha-3(IV) chain
  • collagen type IV alpha3 chain
  • procollagen, type IV, alpha 3
  • tumstatin
  • collagen, type IV, alpha 3 (Goodpasture antigen)
  • collagen IV, alpha-3 polypeptide
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