COCH 产品
(Cochlin (COCH))
Categories
The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94% and 79% amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated. [provided by RefSeq, Oct 2008].
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Featured COCH Categories
COCH 抗体
High quality antibodies with extensive validation data.
COCH ELISA试剂盒
Reliable ELISA kits for a wide range of species.
COCH 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended COCH 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7148039
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
IHC, IF
Validations
- (2)
Cat. No.
ABIN7262425
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (2)
Cat. No.
ABIN514965
Quantity
50 μg
Datasheet
Datasheet
Recommended COCH ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6954851
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN4882435
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6386083
Quantity
96 tests
Datasheet
Datasheet
Recommended COCH 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1349913
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
Cat. No.
ABIN7317572
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
Cat. No.
ABIN6253496
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our COCH Products
: "Cleaved Cochlin Sequesters Pseudomonas aeruginosa and Activates Innate Immunity in the Inner Ear." in: Cell host & microbe, Vol. 25, Issue 4, pp. 513-525.e6, (2019) (PubMed).: "Activation of human endothelial cells via S-endo-1 antigen (CD146) stimulates the tyrosine phosphorylation of focal adhesion kinase p125(FAK)." in: The Journal of biological chemistry, Vol. 273, Issue 41, pp. 26852-6, (1998) (PubMed).
: "Loss of AP-2 results in up-regulation of MCAM/MUC18 and an increase in tumor growth and metastasis of human melanoma cells." in: The Journal of biological chemistry, Vol. 273, Issue 26, pp. 16501-8, (1998) (PubMed).
: "Expression of MCAM/MUC18 by human melanoma cells leads to increased tumor growth and metastasis." in: Cancer research, Vol. 57, Issue 11, pp. 2295-303, (1997) (PubMed).
: "MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 86, Issue 24, pp. 9891-5, (1990) (PubMed).
Synonyms and alternative names related to COCH
cochlin (Coch), cochlin (COCH), AW122937, Coch-5B2, COCH-5B2, COCH5B2, D12H14S564E, DFNA9Protein level used designations for COCH
- coagulation factor C homolog (Limulus polyphemus)
- coagulation factor C homolog, cochlin (Limulus polyphemus)
- cochlin
- Coch-5B2
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