CLCN3 产品
(Chloride Channel 3 (CLCN3))
Categories
This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011].
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Featured CLCN3 Categories
Recommended CLCN3 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, ELISA
Validations
- (3)
Cat. No.
ABIN6260874
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Rat
Application
WB, IHC, ICC, IF
Validations
- (3)
Cat. No.
ABIN1027722
Quantity
100 μg
Datasheet
Datasheet
Recommended CLCN3 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1349568
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3113843
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3134382
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our CLCN3 Products
: "CAPS1 effects on intragranular pH and regulation of BDNF release from secretory granules in hippocampal neurons." in: Journal of cell science, Vol. 129, Issue 7, pp. 1378-90, (2016) (PubMed).: "Novel CLC3 transcript variants in blood eosinophils and increased CLC3 expression in nasal lavage and blood eosinophils of asthmatics." in: Immunity, inflammation and disease, Vol. 2, Issue 4, pp. 205-13, (2015) (PubMed).
: "Chloride-hydrogen antiporters ClC-3 and ClC-5 drive osteoblast mineralization and regulate fine-structure bone patterning in vitro." in: Physiological reports, Vol. 3, Issue 11, (2015) (PubMed).
: "Calcium entry via TRPC1 channels activates chloride currents in human glioma cells." in: Cell calcium, Vol. 53, Issue 3, pp. 187-94, (2013) (PubMed).
: "A quantitative assay for lysosomal acidification rates in human osteoclasts." in: Assay and drug development technologies, Vol. 9, Issue 2, pp. 157-64, (2011) (PubMed).
: "Expression and localization of CLC chloride transport proteins in the avian retina." in: PLoS ONE, Vol. 6, Issue 3, pp. e17647, (2011) (PubMed).
Synonyms and alternative names related to CLCN3
chloride voltage-gated channel 3 (CLCN3), chloride voltage-gated channel 3 (Clcn3), chloride channel, voltage-sensitive 3 (Clcn3), chloride channel 3 (clcn3), chloride channel protein 3 (PTRG_03131), chloride channel protein 3 (BDBG_05668), chloride channel protein 3 (MCYG_04420), chloride channel, voltage-sensitive 3 (clcn3), chloride channel, voltage-sensitive 3 S homeolog (clcn3.S), ClC-3, clc-3, CLC3, Clc3, clc3, CLCN3, fb78c02, wu:fb78c02Protein level used designations for CLCN3
- H(+)/Cl(-) exchange transporter 3
- chloride channel 3
- chloride channel protein 3
- chloride transporter ClC-3
- protein kinase C-regulated chloride channel
- clC-3
- chloride channel Clc-3
- Chloride channel protein 3
- H(+)/Cl(-) exchange transporter 3-like
- putative chloride channel ClC-3
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