CHRNA7 产品
(Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7))
Categories
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012].
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Featured CHRNA7 Categories
CHRNA7 抗体
High quality antibodies with extensive validation data.
CHRNA7 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
CHRNA7 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CHRNA7 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC, FACS
Validations
- (3)
- (7)
Cat. No.
ABIN5611363
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IF (cc), IF (p), ICC, IHC (p), IHC (fro)
Validations
- (5)
Cat. No.
ABIN736911
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, FACS
Validations
- (5)
Cat. No.
ABIN5611362
Quantity
100 μL
Datasheet
Datasheet
Recommended CHRNA7 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6954757
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN418014
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5595336
Quantity
96 tests
Datasheet
Datasheet
Recommended CHRNA7 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122359
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
Cat. No.
ABIN7508493
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7413079
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our CHRNA7 Products
: "Extracellular Vesicles Derived from Metastatic Melanoma Cells Transfer α7-nAChR mRNA, Thus Increasing the Surface Expression of the Receptor and Stimulating the Growth of Normal Keratinocytes." in: Acta naturae, Vol. 14, Issue 3, pp. 95-99, (2022) (PubMed).: "SLURP-1 Controls Growth and Migration of Lung Adenocarcinoma Cells, Forming a Complex With α7-nAChR and PDGFR/EGFR Heterodimer." in: Frontiers in cell and developmental biology, Vol. 9, pp. 739391, (2021) (PubMed).
: "Human Three-Finger Protein Lypd6 Is a Negative Modulator of the Cholinergic System in the Brain." in: Frontiers in cell and developmental biology, Vol. 9, pp. 662227, (2021) (PubMed).
: "Evaluating Commercially Available Antibodies for Rat α7 Nicotinic Acetylcholine Receptors." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 65, Issue 9, pp. 499-512, (2017) (PubMed).
: "Mechanisms of tumor-promoting activities of nicotine in lung cancer: synergistic effects of cell membrane and mitochondrial nicotinic acetylcholine receptors." in: BMC cancer, Vol. 15, pp. 152, (2015) (PubMed).
: "Molecular mechanisms of synergy of corneal muscarinic and nicotinic acetylcholine receptors in upregulation of E-cadherin expression." in: International immunopharmacology, Vol. 29, Issue 1, pp. 15-20, (2015) (PubMed).
: "Different dynamics of aquaporin 4 and glutamate transporter-1 distribution in the perineuronal and perivascular compartments during ischemic stroke." in: Brain pathology (Zurich, Switzerland), Vol. 24, Issue 5, pp. 475-93, (2014) (PubMed).
: "Increased antibodies for the alpha7 subunit of the nicotinic receptor in schizophrenia." in: Schizophrenia research, Vol. 109, Issue 1-3, pp. 98-101, (2009) (PubMed).
: "{alpha}7 nicotinic acetylcholine receptor regulates airway epithelium differentiation by controlling basal cell proliferation." in: The American journal of pathology, Vol. 175, Issue 5, pp. 1868-82, (2009) (PubMed).
: "The alpha7 nicotinic acetylcholine receptor subunit exists in two isoforms that contribute to functional ligand-gated ion channels." in: Molecular pharmacology, Vol. 66, Issue 3, pp. 420-9, (2004) (PubMed).
Synonyms and alternative names related to CHRNA7
cholinergic receptor nicotinic alpha 7 subunit (CHRNA7), neuronal acetylcholine receptor subunit alpha-7 (LOC100374356), cholinergic receptor, nicotinic, alpha 7 (neuronal) (chrna7), cholinergic receptor, nicotinic, alpha polypeptide 7 (Chrna7), cholinergic receptor nicotinic alpha 7 subunit (Chrna7), cholinergic receptor, nicotinic, alpha 7 (CHRNA7), neuronal acetylcholine receptor subunit alpha-7 (LOC100060521), Acra7, alpha7, BTX, CHRNA7, CHRNA7-2, dZ70B1.1, NACHRA7, nAChRa7, NARADProtein level used designations for CHRNA7
- a7 nicotinic acetylcholine receptor
- alpha 7 neuronal nicotinic acetylcholine receptor
- alpha-7 nicotinic cholinergic receptor subunit
- cholinergic receptor, nicotinic, alpha polypeptide 7
- neuronal acetylcholine receptor protein, alpha-7 chain
- neuronal acetylcholine receptor subunit alpha-7
- cholinergic receptor, nicotinic, alpha 7
- neuronal acetylcholine receptor subunit alpha-7-like
- acetylcholine receptor alpha 7 neural
- alpha7 nicotinic receptor
- alpha7-nAChR
- C holinergic receptor nicotinic alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha)
- C holinergic receptor, nicotinic, alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha)
- bungarotoxin alpha
- neuronal nicotinic acetycholine receptor alpha 7
- nicotinic receptor alpha 7 subunit
- cholinergic receptor nicotinic alpha 7
- alpha 7 nicotinic acetylcholine receptor
- nicotinic acetylcholine receptor alpha7
- CHRNA7-FAM7A fusion protein
- cholinergic receptor, nicotinic, alpha 7 (neuronal)
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- Chromatin Target of PRMT1
- Chromogranin A
- Chromosome 1 Open Reading Frame 190
- Chromosome 1 Open Reading Frame 27
- Chromosome 1 Open Reading Frame 61
- Chromosome 1 Open Reading Frame 84
- Chromosome 10 Open Reading Frame 116
- Chromosome 11open Reading Frame 9
- Chromosome 12 Open Reading Frame 39
- Chromosome 12 Open Reading Frame 52
- Chromosome 12 Open Reading Frame 57
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