Chmp1b2 蛋白
(Charged multivesicular body protein 1b-2 (Chmp1b2))
Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT- III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B and SPAST to the midbody of dividing cells (By similarity).
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Synonyms and alternative names related to Chmp1b2
RIKEN cDNA 2610002M06 gene (2610002M06Rik), 8430408J07Rik, AI876413, Chmp1b2Protein level used designations for Chmp1b2
- CHMP1b-2
- charged multivesicular body protein 1b-2
- chromatin-modifying protein 1b-2
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