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CHEK2 蛋白

(Checkpoint Kinase 2 (CHEK2))

In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].

recommended

CHEK2 Protein (AA 1-543) (GST tag) (ABIN1349305)

CHEK2 宿主: 人宿主: 小麦胚 Recombinant WB, ELISA, AA, AP

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recommended

CHEK2 Protein (AA 1-100) (GST tag) (ABIN1349307)

CHEK2 宿主: 人宿主: 小麦胚 Recombinant WB, ELISA, AA, AP

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recommended

CHEK2 Protein (GST tag) (ABIN7317121)

CHEK2 宿主: 人宿主: Baculovirus infected Insect Cells Recombinant > 95 % as determined by reducing SDS-PAGE.

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CHEK2 蛋白 by Origin

Find CHEK2 蛋白 for a variety of species such as anti-Human CHEK2, anti-Mouse CHEK2. The species listed below are among those available. Click on a link to go to the corresponding products.

CHEK2 蛋白 by Source

Here you will find CHEK2 蛋白 proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

CHEK2 蛋白 by 蛋白类型

Here you can find CHEK2 蛋白 proteins categorized by available protein types. Additional protein types can be located using our search function.

CHEK2 蛋白 by 应用范围

Find CHEK2 蛋白 validated for a specific application such as WB, ELISA, SDS, AP. Some of the available applications are listed below. Click on a link to go to the corresponding products.

CHEK2 蛋白 by 生物活性

Find CHEK2 蛋白 with a specific 生物活性. The 生物活性 listed below are among those available. Click on a link to go to the corresponding products.

Popular CHEK2 蛋白

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

CHEK2 Protein (AA 1-543) (GST tag)

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1349305

Quantity 10 μg

Datasheet Datasheet

CHEK2 Protein (AA 1-100) (GST tag)

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1349307

Quantity 10 μg

Datasheet Datasheet

CHEK2 Protein (GST tag)

Reactivity Human

Source Baculovirus infected Insect Cells

Validations

Cat. No. ABIN7317121

Quantity 50 μg

Datasheet Datasheet

CHEK2 Protein (GST tag,His tag)

Reactivity Mouse

Source Baculovirus infected Insect Cells

Validations

Cat. No. ABIN7320011

Quantity 50 μg

Datasheet Datasheet

CHEK2 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN2713979

Quantity 20 μg

Datasheet Datasheet

CHEK2 Protein (GST tag)

Reactivity Human

Source Insect Cells

Validations

Cat. No. ABIN5508871

Quantity 10 μg

Datasheet Datasheet

CHEK2 Protein (AA 300-540) (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7405852

Quantity 100 μg

Datasheet Datasheet

CHEK2 Protein (AA 1-543) (Strep Tag)

Reactivity Human

Source Tobacco (Nicotiana tabacum)

Validations

Cat. No. ABIN3091285

Quantity 1 mg

Datasheet Datasheet

CHEK2 Protein (AA 1-546) (Strep Tag)

Reactivity Mouse

Source Tobacco (Nicotiana tabacum)

Validations

Cat. No. ABIN3137621

Quantity 1 mg

Datasheet Datasheet

Latest Publications for our CHEK2 蛋白

Troncale, Barbet, Coulibaly, Henry, He, Barillot, Dubois, Hupé, de Koning: "NormaCurve: a SuperCurve-based method that simultaneously quantifies and normalizes reverse phase protein array data." in: PLoS ONE, Vol. 7, Issue 6, pp. e38686, (2012) (PubMed).

Yang, Chevolot, Géhin, Solassol, Mange, Souteyrand, Laurenceau: "Improvement of protein immobilization for the elaboration of tumor-associated antigen microarrays: application to the sensitive and specific detection of tumor markers from breast cancer sera." in: Biosensors & bioelectronics, Vol. 40, Issue 1, pp. 385-92, (2012) (PubMed).

Aliases for CHEK2 蛋白

checkpoint kinase 2 (CHEK2) 蛋白
checkpoint kinase 2 (chek2) 蛋白
checkpoint kinase 2 (Chek2) 蛋白
serine/threonine-protein kinase chk2 (MCYG_07308) 蛋白
checkpoint kinase 2 L homeolog (chek2.L) 蛋白
CDS1 蛋白
Cds1 蛋白
cds1 蛋白
chek2 蛋白
CHK2 蛋白
Chk2 蛋白
chk2 蛋白
fa66f08 蛋白
hCds1 蛋白
HuCds1 蛋白
HUCDS1 蛋白
hucds1 蛋白
LFS2 蛋白
lfs2 蛋白
PP1425 蛋白
pp1425 蛋白
RAD53 蛋白
Rad53 蛋白
rad53 蛋白
wu:fa66f08 蛋白
zgc:55865 蛋白

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CHEK2 蛋白 by Origin

CHEK2 蛋白 by Source

CHEK2 蛋白 by 蛋白类型

CHEK2 蛋白 by 应用范围

CHEK2 蛋白 by 生物活性

Popular CHEK2 蛋白

Latest Publications for our CHEK2 蛋白

Aliases for CHEK2 蛋白

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