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CHEK2 抗体

(Checkpoint Kinase 2 (CHEK2))
In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].
CHEK2 抗体  (pThr387) CHEK2 抗体  (pThr387) CHEK2 抗体 (pThr387) (ABIN6256554)

CHEK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

CHEK2 抗体  (AA 1-543) CHEK2 抗体  (AA 1-543) CHEK2 抗体 (AA 1-543) (ABIN950070)

CHEK2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

CHEK2 抗体  (AA 1-543) CHEK2 抗体  (AA 1-543) CHEK2 抗体 (AA 1-543) (ABIN564867)

CHEK2 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 4B7 unconjugated

CHEK2 抗体 by Grade

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CHEK2 抗体 by 适用

Find CHEK2 抗体 for a variety of species such as anti-Human CHEK2, anti-Mouse CHEK2, anti-Rat CHEK2. The species listed below are among those available. Click on a link to go to the corresponding products.

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Find CHEK2 抗体 validated for a specific application such as WB, IF (cc), IF (p), ELISA. Some of the available applications are listed below. Click on a link to go to the corresponding products.

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CHEK2 抗体 by 克隆形成能力

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Popular CHEK2 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF, ICC
Validations
  • (1)
  • (10)
Cat. No. ABIN6256554
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IP
Validations
  • (7)
Cat. No. ABIN950070
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF, IHC (p)
Validations
  • (6)
Cat. No. ABIN564867
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF, ICC
Validations
  • (7)
Cat. No. ABIN6255391
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF, ICC
Validations
  • (12)
Cat. No. ABIN6256592
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF, ICC
Validations
  • (12)
Cat. No. ABIN6256552
Quantity 100 μL
Datasheet Datasheet
Reactivity Dog, Human, Monkey
Application WB, IHC, IF, IHC (p), FACS
Validations
  • (7)
Cat. No. ABIN1497495
Quantity 100 μL
Datasheet Datasheet
Reactivity Dog, Human
Application WB, IHC, IF, IHC (p), IP, FACS
Validations
  • (12)
Cat. No. ABIN1497496
Quantity 100 μL
Datasheet Datasheet
Reactivity Dog, Human
Application WB, IHC, IHC (p), IP, FACS
Validations
  • (9)
Cat. No. ABIN1497497
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (2)
  • (5)
Cat. No. ABIN3023035
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF, IP
Validations
  • (5)
Cat. No. ABIN6138520
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF, IHC (p), FACS
Validations
  • (5)
  • (5)
Cat. No. ABIN1881196
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (4)
Cat. No. ABIN524630
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, ICC
Validations
  • (3)
  • (3)
Cat. No. ABIN1724714
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA, IF (cc), IF (p), IHC (p), FACS, IHC (fro)
Validations
  • (3)
  • (2)
Cat. No. ABIN685867
Quantity 100 μL
Datasheet Datasheet

Latest Publications for our CHEK2 抗体

Mousa, Soliman, Alhumaydhi, Almatroudi, Al Rugaie, Allemailem, Alrumaihi, Khan, Rezk, Aljasir, Alwashmi, Aba Alkhayl, Albutti, Seleem: "Garlic Extract Alleviates Trastuzumab-Induced Hepatotoxicity in Rats Through Its Antioxidant, Anti-Inflammatory, and Antihyperlipidemic Effects." in: Journal of inflammation research, Vol. 14, pp. 6305-6316, (2021) (PubMed).

Liu, Yang, Jing, Ren, Wei, Zhang, Zhang, Duan, Zhou, Sun: "Silica nanoparticle exposure inducing granulosa cell apoptosis and follicular atresia in female Balb/c mice." in: Environmental science and pollution research international, Vol. 25, Issue 4, pp. 3423-3434, (2018) (PubMed).

Wei, Zhang, Ren, Zhang, Liu, Duan, Yu, Li, Peng, Zhou, Sun: "Endosulfan induces cell dysfunction through cycle arrest resulting from DNA damage and DNA damage response signaling pathways." in: The Science of the total environment, Vol. 589, pp. 97-106, (2017) (PubMed).

Xiao, Zheng, Huang, Liu, Zhang, Ma: "Deficiency of 53BP1 inhibits the radiosensitivity of colorectal cancer." in: International journal of oncology, Vol. 49, Issue 4, pp. 1600-8, (2017) (PubMed).

Yao, Huang, Zheng, Liu, Lin, Zhang, Yang, Zhang, Ma: "53BP1 loss induces chemoresistance of colorectal cancer cells to 5-fluorouracil by inhibiting the ATM-CHK2-P53 pathway." in: Journal of cancer research and clinical oncology, Vol. 143, Issue 3, pp. 419-431, (2017) (PubMed).

Peng, Qi, Miao, Ren: "1,2:5,6-dianhydrogalactitol inhibits human glioma cell growth in vivo and in vitro by arresting the cell cycle at G2/M phase." in: Acta pharmacologica Sinica, Vol. 38, Issue 4, pp. 561-570, (2017) (PubMed).

Wang, Wang, Liu, Dong, Hu, Miao, Li, Liu, Zhou, Zhang, Ma, Luo: "ATM Signaling Pathway Is Implicated in the SMYD3-mediated Proliferation and Migration of Gastric Cancer Cells." in: Journal of gastric cancer, Vol. 17, Issue 4, pp. 295-305, (2017) (PubMed).

Ercilla, Llopis, Feu, Aranda, Ernfors, Freire, Agell: "New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress." in: Nucleic acids research, Vol. 44, Issue 10, pp. 4745-62, (2016) (PubMed).

Yin, Jiang, Peng, Cui, Zhou, He, Zuo, Ouyang, Fan, Fang: "The molecular mechanism of G2M cell cycle arrest induced by AFB1 in the jejunum." in: Oncotarget, Vol. 7, Issue 24, pp. 35592-35606, (2016) (PubMed).

Domínguez, Feijoo, Bernal, Ercilla, Agell, Genescà, Tusell: "Centrosome aberrations in human mammary epithelial cells driven by cooperative interactions between p16INK4a deficiency and telomere-dependent genotoxic stress." in: Oncotarget, Vol. 6, Issue 29, pp. 28238-56, (2015) (PubMed).

Aliases for CHEK2 抗体

checkpoint kinase 2 (CHEK2) 抗体
checkpoint kinase 2 (chek2) 抗体
checkpoint kinase 2 (Chek2) 抗体
serine/threonine-protein kinase chk2 (MCYG_07308) 抗体
checkpoint kinase 2 L homeolog (chek2.L) 抗体
CDS1 抗体
Cds1 抗体
cds1 抗体
chek2 抗体
CHK2 抗体
Chk2 抗体
chk2 抗体
fa66f08 抗体
hCds1 抗体
HuCds1 抗体
HUCDS1 抗体
hucds1 抗体
LFS2 抗体
lfs2 抗体
PP1425 抗体
pp1425 抗体
RAD53 抗体
Rad53 抗体
rad53 抗体
wu:fa66f08 抗体
zgc:55865 抗体
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