CHEK2 抗体
(Checkpoint Kinase 2 (CHEK2))
In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].
recommended
CHEK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
recommended
recommended
CHEK2 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 4B7 unconjugated
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CHEK2 抗体 by 适用
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Popular CHEK2 抗体
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Reactivity
Application
Validations
Cat. No.
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Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (1)
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Cat. No.
ABIN6256554
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP
Validations
- (7)
Cat. No.
ABIN950070
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
WB, ELISA, IF, IHC (p)
Validations
- (6)
Cat. No.
ABIN564867
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
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Cat. No.
ABIN6255391
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (12)
Cat. No.
ABIN6256592
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (12)
Cat. No.
ABIN6256552
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Dog, Human, Monkey
Application
WB, IHC, IF, IHC (p), FACS
Validations
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Cat. No.
ABIN1497495
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Dog, Human
Application
WB, IHC, IF, IHC (p), IP, FACS
Validations
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Cat. No.
ABIN1497496
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
WB, IHC, IHC (p), IP, FACS
Validations
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Cat. No.
ABIN1497497
Quantity
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Reactivity
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Cat. No.
ABIN3023035
Quantity
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Datasheet
Datasheet
Reactivity
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Application
WB, IF, IP
Validations
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Cat. No.
ABIN6138520
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, IHC (p), FACS
Validations
- (5)
- (5)
Cat. No.
ABIN1881196
Quantity
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Datasheet
Datasheet
Reactivity
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Application
WB, IF
Validations
- (4)
Cat. No.
ABIN524630
Quantity
50 μg
Datasheet
Datasheet
Reactivity
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Application
WB, ELISA, IHC, ICC
Validations
- (3)
- (3)
Cat. No.
ABIN1724714
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IF (cc), IF (p), IHC (p), FACS, IHC (fro)
Validations
- (3)
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Cat. No.
ABIN685867
Quantity
100 μL
Datasheet
Datasheet
Latest Publications for our CHEK2 抗体
: "Garlic Extract Alleviates Trastuzumab-Induced Hepatotoxicity in Rats Through Its Antioxidant, Anti-Inflammatory, and Antihyperlipidemic Effects." in: Journal of inflammation research, Vol. 14, pp. 6305-6316, (2021) (PubMed).: "Silica nanoparticle exposure inducing granulosa cell apoptosis and follicular atresia in female Balb/c mice." in: Environmental science and pollution research international, Vol. 25, Issue 4, pp. 3423-3434, (2018) (PubMed).
: "Endosulfan induces cell dysfunction through cycle arrest resulting from DNA damage and DNA damage response signaling pathways." in: The Science of the total environment, Vol. 589, pp. 97-106, (2017) (PubMed).
: "Deficiency of 53BP1 inhibits the radiosensitivity of colorectal cancer." in: International journal of oncology, Vol. 49, Issue 4, pp. 1600-8, (2017) (PubMed).
: "53BP1 loss induces chemoresistance of colorectal cancer cells to 5-fluorouracil by inhibiting the ATM-CHK2-P53 pathway." in: Journal of cancer research and clinical oncology, Vol. 143, Issue 3, pp. 419-431, (2017) (PubMed).
: "1,2:5,6-dianhydrogalactitol inhibits human glioma cell growth in vivo and in vitro by arresting the cell cycle at G2/M phase." in: Acta pharmacologica Sinica, Vol. 38, Issue 4, pp. 561-570, (2017) (PubMed).
: "ATM Signaling Pathway Is Implicated in the SMYD3-mediated Proliferation and Migration of Gastric Cancer Cells." in: Journal of gastric cancer, Vol. 17, Issue 4, pp. 295-305, (2017) (PubMed).
: "New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress." in: Nucleic acids research, Vol. 44, Issue 10, pp. 4745-62, (2016) (PubMed).
: "The molecular mechanism of G2M cell cycle arrest induced by AFB1 in the jejunum." in: Oncotarget, Vol. 7, Issue 24, pp. 35592-35606, (2016) (PubMed).
: "Centrosome aberrations in human mammary epithelial cells driven by cooperative interactions between p16INK4a deficiency and telomere-dependent genotoxic stress." in: Oncotarget, Vol. 6, Issue 29, pp. 28238-56, (2015) (PubMed).
Aliases for CHEK2 抗体
checkpoint kinase 2 (CHEK2) 抗体checkpoint kinase 2 (chek2) 抗体
checkpoint kinase 2 (Chek2) 抗体
serine/threonine-protein kinase chk2 (MCYG_07308) 抗体
checkpoint kinase 2 L homeolog (chek2.L) 抗体
CDS1 抗体
Cds1 抗体
cds1 抗体
chek2 抗体
CHK2 抗体
Chk2 抗体
chk2 抗体
fa66f08 抗体
hCds1 抗体
HuCds1 抗体
HUCDS1 抗体
hucds1 抗体
LFS2 抗体
lfs2 抗体
PP1425 抗体
pp1425 抗体
RAD53 抗体
Rad53 抗体
rad53 抗体
wu:fa66f08 抗体
zgc:55865 抗体
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