CHD8 产品
(Chromodomain Helicase DNA Binding Protein 8 (CHD8))
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This gene encodes a DNA helicase that functions as a transcription repressor by remodeling chromatin structure. It binds beta-catenin and negatively regulates Wnt signaling pathway, which plays a pivotal role in vertebrate early development and morphogenesis. Mice lacking this gene exhibit early embryonic death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010].
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CHD8 抗体
High quality antibodies with extensive validation data.
Recommended CHD8 抗体
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Reactivity
Human, Mouse, Rat
Application
WB, IHC, ELISA
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- (3)
Cat. No.
ABIN6260798
Quantity
100 μL
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Datasheet
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Human
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WB, ELISA
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- (1)
Cat. No.
ABIN566153
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50 μL
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WB, ELISA
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Cat. No.
ABIN1774862
Quantity
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Datasheet
Recommended CHD8 蛋白
Latest Publications for our CHD8 Products
: "Common CHD8 Genomic Targets Contrast With Model-Specific Transcriptional Impacts of CHD8 Haploinsufficiency." in: Frontiers in molecular neuroscience, Vol. 11, pp. 481, (2018) (PubMed).: "Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits." in: Cell reports, Vol. 19, Issue 2, pp. 335-350, (2017) (PubMed).
: "BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors." in: Journal of proteomics, Vol. 118, pp. 95-111, (2015) (PubMed).
: "CHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 42, pp. E4468-77, (2014) (PubMed).
: "Frequent disruption of chromodomain helicase DNA-binding protein 8 (CHD8) and functionally associated chromatin regulators in prostate cancer." in: Neoplasia (New York, N.Y.), Vol. 16, Issue 12, pp. 1018-27, (2014) (PubMed).
: "Regulation of serum response factor activity and smooth muscle cell apoptosis by chromodomain helicase DNA-binding protein 8." in: American journal of physiology. Cell physiology, Vol. 299, Issue 5, pp. C1058-67, (2010) (PubMed).
Synonyms and alternative names related to CHD8
chromodomain helicase DNA binding protein 8 (CHD8), chromodomain helicase DNA binding protein 8 (chd8), chromodomain helicase DNA binding protein 8 (Chd8), 5830451P18Rik, AU015341, AUTS18, CHD-8, CHD8, Chd8, Duplin, fi45h08, HELSNF1, mKIAA1564, si:ch211-10e2.6, wu:fi45h08Protein level used designations for CHD8
- chromodomain helicase DNA binding protein 8
- chromodomain-helicase-DNA-binding protein 8
- ATP-dependent helicase CHD8
- chromodomain-helicase-DNA-binding protein 8-like
- axis duplication inhibitor
- duplin
- helicase with SNF2 domain 1
- CHD-8
- beta-catenin binding protein
- chromodomain helicase DNA binding protein family
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