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CHAC1 产品

(ChaC, Cation Transport Regulator Homolog 1 (CHAC1))
Negative regulator of Notch signaling pathway involved furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos. May also act as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (By similarity).

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Featured CHAC1 Categories

CHAC1 抗体

High quality antibodies with extensive validation data.

CHAC1 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

CHAC1 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended CHAC1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, FACS, IF (p), IF (cc), IHC (p), IHC (fro)
Validations
  • (2)
Cat. No. ABIN872557
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC, IF
Validations
  • (2)
Cat. No. ABIN7154130
Quantity 100 μg
Datasheet Datasheet
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
Application WB
Validations
  • (1)
  • (2)
Cat. No. ABIN2773808
Quantity 100 μL
Datasheet Datasheet

Recommended CHAC1 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Competition ELISA
Validations
Cat. No. ABIN1743224
Quantity 96 tests
Datasheet Datasheet
Reactivity Sheep
Analytical Method
Validations
Cat. No. ABIN1774129
Quantity 96 tests
Datasheet Datasheet
Reactivity Dog
Analytical Method
Validations
Cat. No. ABIN1769233
Quantity 96 tests
Datasheet Datasheet

Recommended CHAC1 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN4369905
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3126740
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2713951
Quantity 20 μg
Datasheet Datasheet

Latest Publications for our CHAC1 Products

Chi, Byrne, Dolinko, Harraz, Kim, Umanah, Zhong, Chen, Zhang, Xu, Chen, Pandey, Dawson, Dawson: "Botch is a ?-glutamyl cyclotransferase that deglycinates and antagonizes Notch." in: Cell reports, Vol. 7, Issue 3, pp. 681-8, (2014) (PubMed).

Chi, Zhang, Tokunaga, Harraz, Byrne, Dolinko, Xu, Blackshaw, Gaiano, Dawson, Dawson: "Botch promotes neurogenesis by antagonizing Notch." in: Developmental cell, Vol. 22, Issue 4, pp. 707-20, (2012) (PubMed).

Mungrue, Pagnon, Kohannim, Gargalovic, Lusis: "CHAC1/MGC4504 is a novel proapoptotic component of the unfolded protein response, downstream of the ATF4-ATF3-CHOP cascade." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 1, pp. 466-76, (2008) (PubMed).

Gerhard, Wagner, Feingold, Shenmen, Grouse, Schuler, Klein, Old, Rasooly, Good, Guyer, Peck, Derge, Lipman, Collins, Jang, Sherry, Feolo, Misquitta, Lee, Rotmistrovsky, Greenhut, Schaefer, Buetow et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, (2004) (PubMed).

Synonyms and alternative names related to CHAC1

ChaC glutathione specific gamma-glutamylcyclotransferase 1 (CHAC1), ChaC, cation transport regulator 1 (Chac1), ChaC glutathione-specific gamma-glutamylcyclotransferase 1 (Chac1), 1810008K03Rik, RGD1307153

Protein level used designations for CHAC1

  • cation transport regulator-like protein 1
  • ChaC, cation transport regulator-like 1
  • ChaC, cation transport regulator homolog 1 (E. coli)
  • blocks Notch protein
  • botch
  • cation transport regulator homolog 1
  • neuroprotective protein 7
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