CDK5R1 抗体
(Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1))
The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5)\; the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008].
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Cat. No.
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Quantity
100 μg
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Cat. No.
ABIN2486463
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Human
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Cat. No.
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Cat. No.
ABIN2486461
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100 μg
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Cat. No.
ABIN2486460
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100 μg
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Cat. No.
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Cat. No.
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Cat. No.
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Cat. No.
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Quantity
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Latest Publications for our CDK5R1 抗体
: "Ganetespib (STA-9090), a nongeldanamycin HSP90 inhibitor, has potent antitumor activity in in vitro and in vivo models of non-small cell lung cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 18, Issue 18, pp. 4973-85, (2012) (PubMed).: "CDK5 activator p35 downregulates E-cadherin precursor independently of CDK5." in: FEBS letters, Vol. 582, Issue 8, pp. 1197-202, (2008) (PubMed).
: "Expression of cyclin-dependent kinase 5 mRNA and protein in the human brain following acute ischemic stroke." in: Brain pathology (Zurich, Switzerland), Vol. 17, Issue 1, pp. 11-23, (2007) (PubMed).
: "Increased immunoreactivity of cdk5 activators in hippocampal sclerosis." in: Neuroreport, Vol. 18, Issue 5, pp. 511-6, (2007) (PubMed).
: "Stable association of hsp90 and p23, but Not hsp70, with active human telomerase." in: The Journal of biological chemistry, Vol. 276, Issue 19, pp. 15571-4, (2001) (PubMed).
: "The p23 molecular chaperones act at a late step in intracellular receptor action to differentially affect ligand efficacies." in: Genes & development, Vol. 14, Issue 4, pp. 422-34, (2000) (PubMed).
: "Molecular chaperone machines: chaperone activities of the cyclophilin Cyp-40 and the steroid aporeceptor-associated protein p23." in: Science (New York, N.Y.), Vol. 274, Issue 5293, pp. 1718-20, (1997) (PubMed).
: "Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes." in: Molecular and cellular biology, Vol. 14, Issue 3, pp. 1956-63, (1994) (PubMed).
Aliases for CDK5R1 抗体
cyclin dependent kinase 5 regulatory subunit 1 (CDK5R1) 抗体cyclin-dependent kinase 5, regulatory subunit 1b (p35) (cdk5r1b) 抗体
cyclin-dependent kinase 5 regulatory subunit 1 (Cdk5r1) 抗体
S100 calcium binding protein A9 (S100A9) 抗体
cyclin-dependent kinase 5, regulatory subunit 1 (p35) (Cdk5r1) 抗体
cyclin-dependent kinase 5, regulatory subunit 1 (p35) L homeolog (cdk5r1.L) 抗体
cyclin dependent kinase 5 regulatory subunit 1 (Cdk5r1) 抗体
CDK5P35 抗体
CDK5R 抗体
Cdk5r 抗体
cdk5r1 抗体
CDK5R1 抗体
D11Bwg0379e 抗体
NCK5A 抗体
p23 抗体
p25 抗体
P25/P35 抗体
p35 抗体
p35nck5a 抗体
Xp35.1 抗体
zgc:92814 抗体
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