CDK14 产品
(Cyclin-Dependent Kinase 14 (CDK14))
Categories
Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.
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Featured CDK14 Categories
Recommended CDK14 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, FACS, IHC (p)
Validations
- (5)
Cat. No.
ABIN390748
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC (p)
Validations
- (1)
- (3)
Cat. No.
ABIN391791
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (2)
Cat. No.
ABIN518821
Quantity
50 μg
Datasheet
Datasheet
Recommended CDK14 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6224342
Quantity
96 tests
Datasheet
Datasheet
Recommended CDK14 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1314769
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1314767
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7424140
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our CDK14 Products
: "Activation/Proliferation-associated Protein 2 (Caprin-2) Positively Regulates CDK14/Cyclin Y-mediated Lipoprotein Receptor-related Protein 5 and 6 (LRP5/6) Constitutive Phosphorylation." in: The Journal of biological chemistry, Vol. 291, Issue 51, pp. 26427-26434, (2017) (PubMed).: "Overexpression of PFTK1 predicts resistance to chemotherapy in patients with oesophageal squamous cell carcinoma." in: British journal of cancer, Vol. 106, Issue 5, pp. 947-54, (2012) (PubMed).
: "Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 29, Issue 45, pp. 14309-22, (2009) (PubMed).
: "Cyclin Y, a novel membrane-associated cyclin, interacts with PFTK1." in: FEBS letters, Vol. 583, Issue 13, pp. 2171-8, (2009) (PubMed).
: "Human chromosome 7: DNA sequence and biology. ..." in: Science (New York, N.Y.), Vol. 300, Issue 5620, pp. 767-72, (2003) (PubMed).
: "Identification and cellular localization of human PFTAIRE1." in: Gene, Vol. 267, Issue 2, pp. 165-72, (2001) (PubMed).
Synonyms and alternative names related to CDK14
cyclin dependent kinase 14 (CDK14), cyclin-dependent kinase 14 (Cdk14), cyclin-dependent kinase 14 L homeolog (cdk14.L), mKIAA0834, PFTAIRE1, pftaire1, PFTK1, Pftk1, pftk1Protein level used designations for CDK14
- PFTAIRE protein kinase 1
- cell division protein kinase 14
- hPFTAIRE1
- serine/threonine-protein kinase PFTAIRE-1
- Cell division protein kinase 14
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