CDC27 产品
(Cell Division Cycle 27 Homolog (S. Cerevisiae) (CDC27))
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The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and thus may be involved in controlling the timing of mitosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured CDC27 Categories
Recommended CDC27 抗体
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Reactivity
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Datasheet
Reactivity
Human
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WB, IHC, IF
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Cat. No.
ABIN1679113
Quantity
100 μg
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ELISA, IHC
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Cat. No.
ABIN969035
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100 μL
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ABIN7147307
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Recommended CDC27 ELISA试剂盒
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Quantity
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Recommended CDC27 蛋白
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ABIN3091244
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ABIN3130691
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Reactivity
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Source
Escherichia coli (E. coli)
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Cat. No.
ABIN6239558
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our CDC27 Products
: "Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells." in: Nature methods, Vol. 10, Issue 4, pp. 315-23, (2013) (PubMed).: "Speriolin is a novel spermatogenic cell-specific centrosomal protein associated with the seventh WD motif of Cdc20." in: The Journal of biological chemistry, Vol. 279, Issue 40, pp. 42128-38, (2004) (PubMed).
: "The Apc5 subunit of the anaphase-promoting complex/cyclosome interacts with poly(A) binding protein and represses internal ribosome entry site-mediated translation." in: Molecular and cellular biology, Vol. 24, Issue 9, pp. 3577-87, (2004) (PubMed).
: "Early mitotic degradation of the homeoprotein HOXC10 is potentially linked to cell cycle progression." in: The EMBO journal, Vol. 22, Issue 14, pp. 3715-24, (2003) (PubMed).
: "Perturbation of SUMOlation enzyme Ubc9 by distinct domain within nucleoporin RanBP2/Nup358." in: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 4755-63, (2002) (PubMed).
: "The dephosphorylated form of the anaphase-promoting complex protein Cdc27/Apc3 concentrates on kinetochores and chromosome arms in mitosis." in: Cell cycle (Georgetown, Tex.), Vol. 1, Issue 4, pp. 282-92, (2002) (PubMed).
: "Mitotic regulation of the APC activator proteins CDC20 and CDH1." in: Molecular biology of the cell, Vol. 11, Issue 5, pp. 1555-69, (2000) (PubMed).
: "CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition." in: Cell, Vol. 81, Issue 2, pp. 261-8, (1995) (PubMed).
: "Linking yeast genetics to mammalian genomes: identification and mapping of the human homolog of CDC27 via the expressed sequence tag (EST) data base." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 21, pp. 10031-5, (1993) (PubMed).
Synonyms and alternative names related to CDC27
cell division cycle 27 (CDC27), cell division cycle 27 (cdc27), cell division cycle 27 (Cdc27), cell division cycle 27 S homeolog (cdc27.S), cell division cycle protein 27 homolog (LOC100123129), anaphase-promoting complex subunit Apc3 (nuc2), AI452358, ANAPC3, APC3, BC023187, CDC27, CDC27Hs, D0S1430E, D17S978E, HNUC, NUC2, NV10210, wu:fb54g06, wu:fc88c12Protein level used designations for CDC27
- CDC27 homolog
- H-NUC
- anaphase promoting complex subunit 3
- anaphase-promoting complex subunit 3
- anaphase-promoting complex, protein 3
- cell division cycle 27 homolog
- cell division cycle protein 27 homolog
- nuc2 homolog
- cell division cycle 27 homolog (S. cerevisiae)
- 20S cyclosome/APC complex protein apc3
- Nuclear alteration protein 2
- Nuclear scaffold-like protein p76
- cell division cycle protein 27
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