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CD70 产品

(CD70 Molecule (CD70))

Categories

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008].

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Featured CD70 Categories

CD70 抗体

High quality antibodies with extensive validation data.

CD70 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

CD70 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended CD70 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (6)
Cat. No. ABIN3022743
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application FACS
Validations
  • (3)
  • (2)
Cat. No. ABIN2749184
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human
Application FACS
Validations
  • (4)
  • (2)
Cat. No. ABIN2749173
Quantity 100 tests
Datasheet Datasheet

Recommended CD70 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6973491
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6954532
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN1889449
Quantity 96 tests
Datasheet Datasheet

Recommended CD70 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (4)
Cat. No. ABIN7274227
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (4)
Cat. No. ABIN6961112
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN7274243
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our CD70 Products

Izawa, Martin, Soudais, Bruneau, Boutboul, Rodriguez, Lenoir, Hislop, Besson, Touzot, Picard, Callebaut, de Villartay, Moshous, Fischer, Latour: "Inherited CD70 deficiency in humans reveals a critical role for the CD70-CD27 pathway in immunity to Epstein-Barr virus infection." in: The Journal of experimental medicine, Vol. 214, Issue 1, pp. 73-89, (2017) (PubMed).

Mazor, Hansen, Yang, Chowdhury, Wang, Stephens, Wu, DallAcqua: "Insights into the molecular basis of a bispecific antibody's target selectivity." in: mAbs, Vol. 7, Issue 3, pp. 461-9, (2015) (PubMed).

Trebing, El-Mesery, Schäfer, Weisenberger, Siegmund, Silence, Wajant: "CD70-restricted specific activation of TRAILR1 or TRAILR2 using scFv-targeted TRAIL mutants." in: Cell death & disease, Vol. 5, pp. e1035, (2014) (PubMed).

Hashimoto-Okada, Kitawaki, Kadowaki, Iwata, Morimoto, Hori, Uchiyama: "The CD70-CD27 interaction during the stimulation with dendritic cells promotes naive CD4(+) T cells to develop into T cells producing a broad array of immunostimulatory cytokines in humans." in: International immunology, Vol. 21, Issue 8, pp. 891-904, (2009) (PubMed).

Kaufmann, Amariglio, Rosenthal, Hirsch, Many, Rechavi: "Proliferation response of leukemic cells to CD70 ligation oscillates with recurrent remission and relapse in a low-grade lymphoma." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 10, pp. 6940-7, (2005) (PubMed).

Baki, Marambaud, Efthimiopoulos, Georgakopoulos, Wen, Cui, Shioi, Koo, Ozawa, Friedrich, Robakis: "Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 5, pp. 2381-6, (2001) (PubMed).

Israel, Pickles, Segal, Gerard, Kenney: "Enhancement of adenovirus vector entry into CD70-positive B-cell Lines by using a bispecific CD70-adenovirus fiber antibody." in: Journal of virology, Vol. 75, Issue 11, pp. 5215-21, (2001) (PubMed).

MacLaren, Clark, Gillespie: "v-Jun sensitizes cells to apoptosis by a mechanism involving mitochondrial cytochrome C release." in: Oncogene, Vol. 19, Issue 51, pp. 5906-18, (2000) (PubMed).

Akiba, Miyahira, Atsuta, Takeda, Nohara, Futagawa, Matsuda, Aoki, Yagita, Okumura: "Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis." in: The Journal of experimental medicine, Vol. 191, Issue 2, pp. 375-80, (2000) (PubMed).

Takeda, Oshima, Hayakawa, Akiba, Atsuta, Kobata, Kobayashi, Ito, Yagita, Okumura: "CD27-mediated activation of murine NK cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 4, pp. 1741-5, (2000) (PubMed).

Synonyms and alternative names related to CD70

CD70 antigen (Cd70), CD70 molecule (CD70), Cd70 molecule (Cd70), Cd27l, CD27L, CD27LG, Tnfsf7, TNFSF7

Protein level used designations for CD70

  • CD27 ligand
  • CD27-L
  • Ki-24 antigen
  • tumor necrosis factor (ligand) superfamily, member 7
  • tumor necrosis factor ligand superfamily member 7
  • CD70 antigen
  • surface antigen CD70
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