CD45RB 抗体
(CD45RB)
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012].
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CD45RB 抗体
High quality antibodies with extensive validation data.
Recommended CD45RB 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Non-Human Primate
Application
FACS, WB, IHC (p), IP
Validations
- (1)
- (5)
Cat. No.
ABIN94140
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human, Non-Human Primate
Application
FACS
Validations
- (1)
- (2)
Cat. No.
ABIN94142
Quantity
100 tests
Datasheet
Datasheet
Reactivity
Human, Non-Human Primate
Application
FACS
Validations
- (1)
- (2)
Cat. No.
ABIN94143
Quantity
100 tests
Datasheet
Datasheet
Latest Publications for our CD45RB Products
: "Pivotal advance: CD45RB glycosylation is specifically regulated during human peripheral B cell differentiation." in: Journal of leukocyte biology, Vol. 90, Issue 1, pp. 5-19, (2011) (PubMed).: "Involvement of CD45 in DNA fragmentation in apoptosis induced by mitochondrial perturbing agents." in: Apoptosis : an international journal on programmed cell death, Vol. 13, Issue 2, pp. 197-212, (2008) (PubMed).
: "Collagen-mediated survival signaling is modulated by CD45 in Jurkat T cells." in: Molecular immunology, Vol. 44, Issue 15, pp. 3682-90, (2007) (PubMed).
: "Use of flow cytometry to identify monoclonal antibodies that recognize conserved epitopes on orthologous leukocyte differentiation antigens in goats, llamas, and rabbits." in: Veterinary immunology and immunopathology, Vol. 119, Issue 1-2, pp. 123-30, (2007) (PubMed).
: "Screening of anti-human leukocyte monoclonal antibodies for reactivity with equine leukocytes." in: Veterinary immunology and immunopathology, Vol. 119, Issue 1-2, pp. 63-80, (2007) (PubMed).
: "Altered CD45 isoform expression in C77G carriers influences cytokine responsiveness and adhesion properties of T cells." in: Clinical and experimental immunology, Vol. 150, Issue 3, pp. 509-17, (2007) (PubMed).
: "CD45 isoform expression in microglia and inflammatory cells in HIV-1 encephalitis." in: Brain pathology (Zurich, Switzerland), Vol. 16, Issue 4, pp. 256-65, (2006) (PubMed).
Synonyms and alternative names related to CD45RB
protein tyrosine phosphatase, receptor type C (PTPRC), protein tyrosine phosphatase, receptor type, C (Ptprc), B220, CD45, Cd45, CD45R, GP180, L-CA, LCA, loc, Ly-5, LY5, Lyt-4, T200Protein level used designations for CD45RB
- CD45 antigen
- T200 glycoprotein
- T200 leukocyte common antigen
- protein tyrosine phosphatase, receptor type, c polypeptide
- receptor-type tyrosine-protein phosphatase C
- leukocyte common antigen
- lymphocyte antigen 5
- lymphocyte common antigen
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