CD45RA 产品
(CD45RA)
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The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012].
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Featured CD45RA Categories
CD45RA 抗体
High quality antibodies with extensive validation data.
Recommended CD45RA 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
FACS, IHC (p), WB, IP, CyTOF
Validations
- (1)
- (5)
Cat. No.
ABIN94136
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human
Application
FACS
Validations
- (1)
- (4)
Cat. No.
ABIN125695
Quantity
100 tests
Datasheet
Datasheet
Reactivity
Human
Application
IHC
Validations
- (3)
Cat. No.
ABIN7477415
Quantity
1 mL
Datasheet
Datasheet
Recommended CD45RA 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Human Cells
Validations
- (1)
Cat. No.
ABIN7319928
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our CD45RA Products
: "Epigenetics modifications and Subclinical Atherosclerosis in Obstructive Sleep Apnea: The EPIOSA study." in: BMC pulmonary medicine, Vol. 14, pp. 114, (2015) (PubMed).: "Vaccine protection from CD4+ T-cell loss caused by simian immunodeficiency virus (SIV) mac251 is afforded by sequential immunization with three unrelated vaccine vectors encoding multiple SIV antigens." in: The Journal of general virology, Vol. 85, Issue Pt 10, pp. 2915-24, (2004) (PubMed).
: "Distinctive response of naïve lymphocytes from cord blood to primary activation via TCR." in: Journal of leukocyte biology, Vol. 74, Issue 6, pp. 998-1007, (2003) (PubMed).
: "Activation of human dendritic cells is modulated by components of the outer membranes of Neisseria meningitidis." in: Infection and immunity, Vol. 71, Issue 10, pp. 5590-7, (2003) (PubMed).
: "Control of intracellular dynamics of mammalian period proteins by casein kinase I epsilon (CKIepsilon) and CKIdelta in cultured cells." in: Molecular and cellular biology, Vol. 22, Issue 6, pp. 1693-703, (2002) (PubMed).
: "Recruitment of intestinal CD45RA+ and CD45RC+ cells induced by a candidate oral vaccine against porcine post-weaning colibacillosis." in: Veterinary immunology and immunopathology, Vol. 86, Issue 3-4, pp. 137-46, (2002) (PubMed).
: "Immunophenotyping of leukocyte subsets in peripheral blood and palatine tonsils of prefattening pigs." in: Veterinary research communications, Vol. 26, Issue 4, pp. 273-83, (2002) (PubMed).
: "CD45 controls interleukin-4-mediated IgE class switch recombination in human B cells through its function as a Janus kinase phosphatase." in: The Journal of biological chemistry, Vol. 277, Issue 32, pp. 28830-5, (2002) (PubMed).
: "Synergistic activation of the Wnt signaling pathway by Dvl and casein kinase Iepsilon." in: The Journal of biological chemistry, Vol. 276, Issue 35, pp. 33147-55, (2001) (PubMed).
: "TGF-beta1 enhances SDF-1alpha-induced chemotaxis and homing of naive T cells by up-regulating CXCR4 expression and downstream cytoskeletal effector molecules." in: European journal of immunology, Vol. 32, Issue 1, pp. 193-202, (2001) (PubMed).
Synonyms and alternative names related to CD45RA
protein tyrosine phosphatase, receptor type C (PTPRC), protein tyrosine phosphatase, receptor type, C (Ptprc), B220, CD45, CD45R, GP180, L-CA, LCA, Lca, LY5, RT7, T200Protein level used designations for CD45RA
- CD45 antigen
- T200 glycoprotein
- T200 leukocyte common antigen
- protein tyrosine phosphatase, receptor type, c polypeptide
- receptor-type tyrosine-protein phosphatase C
- Protein tyrosine phosphatase, receptor-type, c polypeptide
- leucocyte common antigen
- leukocyte common antigen A
- leukocyte common antigen B
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