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CD35 产品

(Complement Component Receptor 1 (CD35) (CR1))

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This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008].

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Featured CD35 Categories

CD35 抗体

High quality antibodies with extensive validation data.

CD35 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

Recommended CD35 抗体

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Cat. No. ABIN7266477
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Cat. No. ABIN7148407
Quantity 100 μL
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Recommended CD35 ELISA试剂盒

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Reactivity
Analytical Method
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Cat. No.
Quantity
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Reactivity Human
Analytical Method Quantitative Sandwich ELISA
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Cat. No. ABIN6955049
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
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Cat. No. ABIN6962520
Quantity 96 tests
Datasheet Datasheet
Reactivity Chicken
Analytical Method Quantitative Competition ELISA
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Cat. No. ABIN1052414
Quantity 96 tests
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Recommended CD35 蛋白

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Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
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Cat. No. ABIN7393268
Quantity 100 μg
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Reactivity Human
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Cat. No. ABIN3008960
Quantity 100 μg
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Latest Publications for our CD35 Products

Goetzl, Yaffe, Peltz, Ledreux, Gorgens, Davidson, Granholm, Mustapic, Kapogiannis, Tweedie, Greig: "Traumatic brain injury increases plasma astrocyte-derived exosome levels of neurotoxic complement proteins." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 34, Issue 2, pp. 3359-3366, (2020) (PubMed).

Dave, Sharma, Muir, Haddad, Gumber, Villinger, Nehra, Khan, Wigdahl, Ansari, Byrareddy, Jain: "FDC:TFH Interactions within Cervical Lymph Nodes of SIV-Infected Rhesus Macaques." in: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, Vol. 13, Issue 2, pp. 204-218, (2019) (PubMed).

Sandri, Lidani, Andrade, Meyer, Kremsner, de Messias-Reason, Velavan: "Human complement receptor type 1 (CR1) protein levels and genetic variants in chronic Chagas Disease." in: Scientific reports, Vol. 8, Issue 1, pp. 526, (2018) (PubMed).

Goetzl, Schwartz, Abner, Jicha, Kapogiannis: "High complement levels in astrocyte-derived exosomes of Alzheimer disease." in: Annals of neurology, Vol. 83, Issue 3, pp. 544-552, (2018) (PubMed).

Rovituso, Scheffler, Wunsch, Kleinschnitz, Dörck, Ulzheimer, Bayas, Steinman, Ergün, Kuerten: "CEACAM1 mediates B cell aggregation in central nervous system autoimmunity." in: Scientific reports, Vol. 6, pp. 29847, (2016) (PubMed).

Avanzi, Leoni, Rotola, Alviano, Solimando, Lanzoni, Bonsi, Di Luca, Marchionni, Alvisi, Ripalti: "Susceptibility of human placenta derived mesenchymal stromal/stem cells to human herpesviruses infection." in: PLoS ONE, Vol. 8, Issue 8, pp. e71412, (2013) (PubMed).

Daborg, Andreasson, Pekna, Lautner, Hanse, Minthon, Blennow, Hansson, Zetterberg: "Cerebrospinal fluid levels of complement proteins C3, C4 and CR1 in Alzheimer's disease." in: Journal of neural transmission (Vienna, Austria : 1996), Vol. 119, Issue 7, pp. 789-97, (2012) (PubMed).

Schwartz, Barker, Long, Kaufman, McCracken, Allen: "Natural IgM mediates complement-dependent uptake of Francisella tularensis by human neutrophils via complement receptors 1 and 3 in nonimmune serum." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 189, Issue 6, pp. 3064-77, (2012) (PubMed).

Zhang, Patel, Dey, Ghorani, Rai, Elham, Castleton, Fielding: "Attenuated, oncolytic, but not wild-type measles virus infection has pleiotropic effects on human neutrophil function." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 188, Issue 3, pp. 1002-10, (2012) (PubMed).

Mokuda, Doi, Takasugi: "Simultaneous quantitative analysis of the expression of CD64 and CD35 on neutrophils as markers to differentiate between bacterial and viral infections in patients with rheumatoid arthritis." in: Modern rheumatology, Vol. 22, Issue 5, pp. 750-7, (2012) (PubMed).

Synonyms and alternative names related to CD35

complement C3b/C4b receptor 1 (Knops blood group) (CR1), complement receptor 2 (Cr2), complement component (3d/Epstein Barr virus) receptor 2 (CR2), complement receptor type 1 (LOC718120), C3BR, C3DR, C4BR, CD21, CD35, Cr-1, Cr-2, Cr1, CR1, CR1-L, CR2, KN

Protein level used designations for CD35

  • C3-binding protein
  • C3b/C4b receptor
  • CD35 antigen
  • Knops blood group antigen
  • complement component receptor 1
  • complement receptor type 1
  • complement C3d receptor
  • complement receptor type 2
  • expressed in B lymphocytes
  • LOW QUALITY PROTEIN: complement receptor type 1
  • complement component (3b/4b) receptor 1 (Knops blood group)
  • complement component (3d/Epstein Barr virus) receptor 2
  • complement receptor type 1-like protein
  • cr1 (CD35)
  • complement receptor 1
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