CCR9 产品
(Chemokine (C-C Motif) Receptor 9 (CCR9))
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The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract. This gene is mapped to the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].
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Latest Publications for our CCR9 Products
: "A Subset of CCL25-Induced Gut-Homing T Cells Affects Intestinal Immunity to Infection and Cancer." in: Frontiers in immunology, Vol. 10, pp. 271, (2019) (PubMed).: "Human Mucosa-Associated Invariant T Cells Accumulate in Colon Adenocarcinomas but Produce Reduced Amounts of IFN-γ." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 195, Issue 7, pp. 3472-81, (2015) (PubMed).
: "Retinoic acid primes human dendritic cells to induce gut-homing, IL-10-producing regulatory T cells." in: Mucosal immunology, Vol. 8, Issue 2, pp. 265-78, (2015) (PubMed).
: "Altered generation of induced regulatory T cells in the FVB.mdr1a-/- mouse model of colitis." in: Mucosal immunology, Vol. 6, Issue 2, pp. 309-23, (2013) (PubMed).
: "TLR activation excludes circulating naive CD8+ T cells from gut-associated lymphoid organs in mice." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 190, Issue 10, pp. 5313-20, (2013) (PubMed).
: "Anti-IL-7 receptor-? reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 31, pp. 12674-9, (2012) (PubMed).
: "A subset of interleukin-21+ chemokine receptor CCR9+ T helper cells target accessory organs of the digestive system in autoimmunity." in: Immunity, Vol. 34, Issue 4, pp. 602-15, (2011) (PubMed).
: "CCL25 mediates migration, invasion and matrix metalloproteinase expression by breast cancer cells in a CCR9-dependent fashion." in: International journal of oncology, Vol. 38, Issue 5, pp. 1279-85, (2011) (PubMed).
: "Identification of human NK17/NK1 cells." in: PLoS ONE, Vol. 6, Issue 10, pp. e26780, (2011) (PubMed).
: "Increased numbers of immature plasma cells in peripheral blood specifically overexpress chemokine receptor CXCR3 and CXCR4 in patients with ulcerative colitis." in: Clinical and experimental immunology, Vol. 163, Issue 2, pp. 215-24, (2011) (PubMed).
Synonyms and alternative names related to CCR9
C-C motif chemokine receptor 9 (CCR9), chemokine (C-C motif) receptor 9 (Ccr9), C-C motif chemokine receptor 9 (Ccr9), A130091K22Rik, CC-CKR-9, CDw199, Cmkbr10, GPR-9-6, GPR28Protein level used designations for CCR9
- C-C chemokine receptor type 9
- G protein-coupled receptor 28
- C-C CKR-9
- CC-CKR-9
- CCR-9
- chemokine C-C receptor 10
- chemokine C-C motif receptor 9
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