CCR5 产品
(Chemokine (C-C Motif) Receptor 5 (CCR5))
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This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
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CCR5 抗体
High quality antibodies with extensive validation data.
CCR5 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
CCR5 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
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Application
IHC (fro)
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Cat. No.
ABIN6939154
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Rat
Application
WB, ELISA, FACS, IHC, ICC, Neut
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Cat. No.
ABIN5611203
Quantity
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Reactivity
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Recommended CCR5 ELISA试剂盒
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Cat. No.
ABIN6965712
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Datasheet
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Latest Publications for our CCR5 Products
: "Hippocampal CCR5/RANTES Elevations in a Rodent Model of Post-Traumatic Stress Disorder: Maraviroc (a CCR5 Antagonist) Increases Corticosterone Levels and Enhances Fear Memory Consolidation." in: Biomolecules, Vol. 10, Issue 2, (2020) (PubMed).: "Methamphetamine abuse affects gene expression in brain-derived microglia of SIV-infected macaques to enhance inflammation and promote virus targets." in: BMC immunology, Vol. 17, Issue 1, pp. 7, (2016) (PubMed).
: "CIB1 and CIB2 are HIV-1 helper factors involved in viral entry." in: Scientific reports, Vol. 6, pp. 30927, (2016) (PubMed).
: "Structural Insights into the Inhibitory Mechanism of an Antibody against B7-H6, a Stress-Induced Cellular Ligand for the Natural Killer Cell Receptor NKp30." in: Journal of molecular biology, Vol. 428, Issue 22, pp. 4457-4466, (2016) (PubMed).
: "Serum concentrations of chemokines (CCL-5 and CXCL-12), chemokine receptors (CCR-5 and CXCR-4), and IL-6 in patients with posttraumatic stress disorder and avoidant personality disorder." in: Pharmacological reports : PR, Vol. 67, Issue 6, pp. 1251-8, (2015) (PubMed).
: "A Linear Epitope in the N-Terminal Domain of CCR5 and Its Interaction with Antibody." in: PLoS ONE, Vol. 10, Issue 6, pp. e0128381, (2015) (PubMed).
: "CXCR4 expression on pathogenic T cells facilitates their bone marrow infiltration in a mouse model of aplastic anemia." in: Blood, Vol. 125, Issue 13, pp. 2087-94, (2015) (PubMed).
: "The effects of CCR5 inhibition on regulatory T-cell recruitment to colorectal cancer." in: British journal of cancer, Vol. 112, Issue 2, pp. 319-28, (2015) (PubMed).
: "Comparison of chemokines (CCL-5 and SDF-1), chemokine receptors (CCR-5 and CXCR-4) and IL-6 levels in patients with different severities of depression." in: Pharmacological reports : PR, Vol. 66, Issue 5, pp. 920-6, (2014) (PubMed).
: "CCR5 receptor antagonists block metastasis to bone of v-Src oncogene-transformed metastatic prostate cancer cell lines." in: Cancer research, Vol. 74, Issue 23, pp. 7103-14, (2014) (PubMed).
Synonyms and alternative names related to CCR5
C-C motif chemokine receptor 5 (gene/pseudogene) (CCR5), chemokine (C-C motif) receptor 5 (Ccr5), chemokine (C-C motif) receptor 5 (CCR5), C-C motif chemokine receptor 5 (CCR5), AM4-7, CC-CKR-5, CCCKR5, CCR-5, CCR1-L, CCR5, CD195, CKR-5, CKR5, Ckr5, CMKBR5, Cmkbr5, GPCR, IDDM22Protein level used designations for CCR5
- C-C chemokine receptor type 5
- C-C motif chemokine receptor 5 A159A
- HIV-1 fusion coreceptor
- chemokine receptor CCR5
- chemr13
- C-C CKR-5
- CC-CKR-5
- CCR-5
- MIP-1 alpha receptor
- chemokine (C-C) receptor 5
- chemokine C-C motif receptor 5
- C-C chemokine receptor 11 like
- CC chemokine receptor 5
- chemokine receptor 5
- CC chemokine receptor type 5
- C-C chemokine receptor 5
- chemokine (C-C motif) receptor 5
- C-C chemokine receptor type 5-like
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