CCM2 产品
(Cerebral Cavernous Malformation 2 (CCM2))
Categories
This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009].
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Featured CCM2 Categories
CCM2 抗体
High quality antibodies with extensive validation data.
CCM2 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
CCM2 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CCM2 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Rat
Application
WB, IF, ELISA, FACS
Validations
- (5)
Cat. No.
ABIN185733
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (4)
Cat. No.
ABIN6138069
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
IHC
Validations
- (3)
Cat. No.
ABIN7262401
Quantity
200 μL
Datasheet
Datasheet
Recommended CCM2 ELISA试剂盒
Recommended CCM2 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122246
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1348426
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1348424
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our CCM2 Products
: "Defective autophagy is a key feature of cerebral cavernous malformations." in: EMBO molecular medicine, Vol. 7, Issue 11, pp. 1403-17, (2015) (PubMed).: "CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis." in: Human molecular genetics, Vol. 14, Issue 17, pp. 2521-31, (2005) (PubMed).
Synonyms and alternative names related to CCM2
CCM2 scaffolding protein (CCM2), CCM2 scaffolding protein (Ccm2), cerebral cavernous malformation 2 (Ccm2), malcavernin (LOC100304744), cerebral cavernous malformation 2 (ccm2), BC029157, C7orf22, CCM2, malcavernin, OSM, TUF2, vtn, zgc:110233Protein level used designations for CCM2
- cerebral cavernous malformations 2 protein
- malcavernin
- cerebral cavernous malformation 2
- cerebral cavernous malformation 2 homolog
- cerebral cavernous malformations protein 2 homolog
- osmosensing scaffold for MEKK3
- Malcavernin
- Valentine
- valentine
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