CCDC98 产品
(Family with Sequence Similarity 175, Member A (FAM175A))
Categories
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of brca1 (By similarity).
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Featured CCDC98 Categories
Recommended CCDC98 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (2)
Cat. No.
ABIN872878
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP, IHC, IHC (p), FACS
Validations
- (2)
Cat. No.
ABIN574440
Quantity
0.05 mg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP, FACS
Validations
- (2)
Cat. No.
ABIN1302443
Quantity
0.1 mg
Datasheet
Datasheet
Recommended CCDC98 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6227801
Quantity
96 tests
Datasheet
Datasheet
Recommended CCDC98 蛋白
Latest Publications for our CCDC98 Products
: "CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response." in: Nature structural & molecular biology, Vol. 14, Issue 8, pp. 710-5, (2007) (PubMed).: "CCDC98 targets BRCA1 to DNA damage sites." in: Nature structural & molecular biology, Vol. 14, Issue 8, pp. 716-20, (2007) (PubMed).
: "Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response." in: Science (New York, N.Y.), Vol. 316, Issue 5828, pp. 1194-8, (2007) (PubMed).
Synonyms and alternative names related to CCDC98
abraxas 1, BRCA1 A complex subunit (ABRAXAS1), Coiled-coil domain-containing protein 98 (abraxas1), BRCA1 A complex subunit (Abraxas1), abraxas 1, BRCA1 A complex subunit (Abraxas1), family with sequence similarity 175 member A (FAM175A), abraxas 2a, BRISC complex subunit (abraxas2a), abraxas 1, BRCA1 A complex subunit S homeolog (abraxas1.S), 3830405G04Rik, 5630400M01Rik, abra1, ABRA1, AI506069, AL024423, AV118690, CCDC98, ccdc98, Ccdc98, fam175a, RGD1305287, zgc:103522Protein level used designations for CCDC98
- coiled-coil domain containing 98
- BRCA1-A complex subunit Abraxas
- Protein FAM175A
- abraxas protein
- coiled-coil domain-containing protein 98
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