CBX4 抗体
(Chromobox Homolog 4 (CBX4))
E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones\; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
recommended
recommended
recommended
CBX4 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
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Find available monoclonal or polyclonal CBX4 抗体. Click on a link to go to the corresponding products.
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Popular CBX4 抗体
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Validations
Cat. No.
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Datasheet
Reactivity
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Application
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Cat. No.
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Quantity
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Datasheet
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Cat. No.
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Quantity
100 μg
Datasheet
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Cat. No.
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Cat. No.
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Quantity
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Cat. No.
ABIN948698
Quantity
50 μg
Datasheet
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Application
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Cat. No.
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Quantity
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Datasheet
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Cat. No.
ABIN389086
Quantity
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Datasheet
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Reactivity
Cow, Dog, Guinea Pig, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
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WB, IHC
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Cat. No.
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IHC, IF, IHC (p)
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Cat. No.
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Quantity
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Datasheet
Datasheet
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Quantity
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Cat. No.
ABIN389087
Quantity
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Datasheet
Datasheet
Reactivity
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Cat. No.
ABIN7306480
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IHC (p), IHC (fro)
Validations
Cat. No.
ABIN2559521
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
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Validations
Cat. No.
ABIN2803302
Quantity
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Datasheet
Datasheet
Reactivity
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Application
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Validations
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Quantity
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Datasheet
Datasheet
Latest Publications for our CBX4 抗体
: "HIF-1α SUMOylation affects the stability and transcriptional activity of HIF-1α in human lens epithelial cells." in: Graefe's archive for clinical and experimental ophthalmology, Vol. 253, Issue 8, pp. 1279-90, (2015) (PubMed).: "Oxidative stress-induced p53 activity is enhanced by a redox-sensitive TP53INP1 SUMOylation." in: Cell death and differentiation, Vol. 21, Issue 7, pp. 1107-18, (2014) (PubMed).
: "Contribution of CBX4 to cumulus oophorus cell phenotype in mice and attendant effects in cumulus cell cloned embryos." in: Physiological genomics, Vol. 46, Issue 2, pp. 66-80, (2014) (PubMed).
: "CBX4-mediated SUMO modification regulates BMI1 recruitment at sites of DNA damage." in: Nucleic acids research, Vol. 40, Issue 12, pp. 5497-510, (2012) (PubMed).
: "Human Polycomb protein 2 promotes ?-synuclein aggregate formation through covalent SUMOylation." in: Brain research, Vol. 1381, pp. 78-89, (2011) (PubMed).
: "The SUMO E3 ligase activity of Pc2 is coordinated through a SUMO interaction motif." in: Molecular and cellular biology, Vol. 30, Issue 9, pp. 2193-205, (2010) (PubMed).
: "Different polycomb group CBX family proteins associate with distinct regions of chromatin using nonhomologous protein sequences." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 43, pp. 16572-7, (2008) (PubMed).
: "Regulation of the SUMO pathway sensitizes differentiating human endometrial stromal cells to progesterone." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 44, pp. 16272-7, (2006) (PubMed).
: "The polycomb protein Pc2 is a SUMO E3." in: Cell, Vol. 113, Issue 1, pp. 127-37, (2003) (PubMed).
Aliases for CBX4 抗体
chromobox 4 (CBX4) 抗体chromobox 4 (Cbx4) 抗体
chromobox 4 S homeolog (cbx4.S) 抗体
chromobox homolog 4 (CBX4) 抗体
chromobox homolog 4 (Pc class homolog, Drosophila) (cbx4) 抗体
cbx4-a 抗体
im:6911625 抗体
MPc2 抗体
NBP16 抗体
PC2 抗体
XPolycomb 抗体
zgc:158588 抗体
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