CBP 产品
(CREB Binding Protein (CREBBP))
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This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009].
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Featured CBP Categories
CBP 抗体
High quality antibodies with extensive validation data.
CBP ELISA试剂盒
Reliable ELISA kits for a wide range of species.
CBP 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CBP 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF, IP, IHC (p), ICC, ChIP
Validations
- (1)
- (9)
- (1)
Cat. No.
ABIN2854987
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, ELISA, IF, ICC
Validations
- (5)
Cat. No.
ABIN6260516
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, PLA
Validations
- (4)
Cat. No.
ABIN560465
Quantity
100 μg
Datasheet
Datasheet
Recommended CBP ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955103
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955104
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1381381
Quantity
96 tests
Datasheet
Datasheet
Recommended CBP 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122497
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1350309
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (2)
Cat. No.
ABIN2669638
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our CBP Products
: "A new cut&run low volume-urea (LoV-U) protocol optimized for transcriptional co-factors uncovers Wnt/b-catenin tissue-specific genomic targets." in: Development (Cambridge, England), (2022) (PubMed).: "Enriched environment modulates behavior, myelination and augments molecules governing the plasticity in the forebrain region of rats exposed to chronic immobilization stress." in: Metabolic brain disease, Vol. 34, Issue 3, pp. 875-887, (2020) (PubMed).
: "DYRK1A interacts with histone acetyl transferase p300 and CBP and localizes to enhancers." in: Nucleic acids research, (2018) (PubMed).
: "Tamoxifen Resistance in Breast Cancer Is Regulated by the EZH2-ERα-GREB1 Transcriptional Axis." in: Cancer research, Vol. 78, Issue 3, pp. 671-684, (2017) (PubMed).
: "Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. ..." in: Nature genetics, Vol. 44, Issue 10, pp. 1104-10, (2012) (PubMed).
: "Protein aggregation in motor neurone disorders." in: Neuropathology and applied neurobiology, Vol. 29, Issue 6, pp. 529-45, (2003) (PubMed).
Synonyms and alternative names related to CBP
CREB binding protein (CREBBP), CREB binding protein (Crebbp), CREB binding protein L homeolog (crebbp.L), histone acetyltransferase p300 (LOC100123220), AW558298, CBP, cbp, CBP/p300, crebbp, hmm291030, KAT3A, kat3a, Nejire, p300/CBP, RSTS, rsts, RTSProtein level used designations for CBP
- CREB-binding protein
- CREB binding protein (Rubinstein-Taybi syndrome)
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