Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase 产品
(Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB))
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E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B- cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T- cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. {ECO:0000269|PubMed:10646608, ECO:0000269|PubMed:10646609, ECO:0000269|PubMed:11070165, ECO:0000269|PubMed:11526404, ECO:0000269|PubMed:12771181, ECO:0000269|PubMed:15308098}.
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Featured Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Categories
Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase 抗体
High quality antibodies with extensive validation data.
Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase ELISA试剂盒
Reliable ELISA kits for a wide range of species.
Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (2)
Cat. No.
ABIN760256
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
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Validations
- (2)
Cat. No.
ABIN6260515
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
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Validations
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Cat. No.
ABIN3015830
Quantity
100 μL
Datasheet
Datasheet
Recommended Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase ELISA试剂盒
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Reactivity
Analytical Method
Validations
Cat. No.
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Datasheet
Reactivity
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Analytical Method
Quantitative Sandwich ELISA
Validations
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Cat. No.
ABIN6965529
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1131076
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
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Validations
Cat. No.
ABIN6200984
Quantity
96 tests
Datasheet
Datasheet
Recommended Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase 蛋白
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Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1348172
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122186
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
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Cat. No.
ABIN1348174
Quantity
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Datasheet
Datasheet
Latest Publications for our Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Products
: "Pro-oncogenic Roles of HLXB9 Protein in Insulinoma Cells through Interaction with Nono Protein and Down-regulation of the c-Met Inhibitor Cblb (Casitas B-lineage Lymphoma b)." in: The Journal of biological chemistry, Vol. 290, Issue 42, pp. 25595-608, (2015) (PubMed).: "Cbl-b mediates TGF? sensitivity by downregulating inhibitory SMAD7 in primary T cells." in: Journal of molecular cell biology, Vol. 5, Issue 6, pp. 358-68, (2013) (PubMed).
: "The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 14, pp. 6459-64, (2010) (PubMed).
Synonyms and alternative names related to Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase
Cbl proto-oncogene B, E3 ubiquitin protein ligase S homeolog (cblb.S), Cbl proto-oncogene B, E3 ubiquitin protein ligase L homeolog (cblb.L), Casitas B-lineage lymphoma b (Cblb), Cbl proto-oncogene B (Cblb), Cbl proto-oncogene B (CBLB), AI429560, AI851073, Cbl-b, cblb, rnf56Protein level used designations for Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase
- Cas-Br-M (murine) ecotropic retroviral transforming sequence b
- Cbl proto-oncogene, E3 ubiquitin protein ligase B
- E3 ubiquitin-protein ligase CBL-B-B
- SH3-binding protein CBL-B-B
- signal transduction protein CBL-B-B
- E3 ubiquitin-protein ligase CBL-B-A
- SH3-binding protein CBL-B-A
- signal transduction protein CBL-B-A
- Casitas B-lineage lymphoma proto-oncogene b
- E3 ubiquitin-protein ligase CBL-B
- RING-type E3 ubiquitin transferase CBL-B
- SH3-binding protein CBL-B
- Signal transduction protein CBL-B
- casitas B-lineage lymphoma proto-oncogene b
- signal transduction protein CBL-B
- Cas-Br-M (murine) ectropic retroviral transforming sequence b
- Casitas B-lineage lymphoma b
- Cbl proto-oncogene B, E3 ubiquitin protein ligase
- LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase CBL-B
- Cas-Br-M ecotropic retroviral transforming sequence b
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