This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Mar 2012].
Find CBL 蛋白 with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.
CBL 蛋白 by Origin
Find CBL 蛋白 for a variety of species such as anti-Human CBL, anti-Mouse CBL. The species listed below are among those available. Click on a link to go to the corresponding products.
CBL 蛋白 by Source
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CBL 蛋白 by 蛋白类型
Here you can find CBL 蛋白 proteins categorized by available protein types. Additional protein types can be located using our search function.
CBL 蛋白 by 应用范围
Find CBL 蛋白 validated for a specific application such as WB, SDS, ELISA, AP. Some of the available applications are listed below. Click on a link to go to the corresponding products.
