CBL 抗体
(Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL))
This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Mar 2012].
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CBL 抗体 by Grade
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CBL 抗体 by 适用
Find CBL 抗体 for a variety of species such as anti-Human CBL, anti-Rat CBL, anti-Mouse CBL. The species listed below are among those available. Click on a link to go to the corresponding products.
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CBL 抗体 by 克隆
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Validations
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Application
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Cat. No.
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Quantity
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Cat. No.
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Quantity
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Quantity
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Datasheet
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Quantity
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Datasheet
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Datasheet
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Latest Publications for our CBL 抗体
: "Cbl negatively regulates JNK activation and cell death." in: Cell research, Vol. 19, Issue 8, pp. 950-61, (2009) (PubMed).: "Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms. ..." in: Nature, Vol. 460, Issue 7257, pp. 904-8, (2009) (PubMed).
: "Mutations in CBL occur frequently in juvenile myelomonocytic leukemia. ..." in: Blood, Vol. 114, Issue 9, pp. 1859-63, (2009) (PubMed).
: "The Cbl family proteins: ring leaders in regulation of cell signaling." in: Journal of cellular physiology, Vol. 209, Issue 1, pp. 21-43, (2006) (PubMed).
: "c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses." in: The Biochemical journal, Vol. 391, Issue Pt 2, pp. 153-66, (2005) (PubMed).
: "Grb2 regulates internalization of EGF receptors through clathrin-coated pits." in: Molecular biology of the cell, Vol. 14, Issue 3, pp. 858-70, (2003) (PubMed).
: "Cbl-mediated ubiquitinylation and negative regulation of Vav." in: The Journal of biological chemistry, Vol. 278, Issue 40, pp. 38495-504, (2003) (PubMed).
: "Cbl: many adaptations to regulate protein tyrosine kinases." in: Nature reviews. Molecular cell biology, Vol. 2, Issue 4, pp. 294-307, (2001) (PubMed).
: "Beyond the RING: CBL proteins as multivalent adapters." in: Oncogene, Vol. 20, Issue 44, pp. 6382-402, (2001) (PubMed).
: "Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking." in: Molecular biology of the cell, Vol. 12, Issue 6, pp. 1897-910, (2001) (PubMed).
Aliases for CBL 抗体
Casitas B-lineage lymphoma (Cbl) 抗体Cbl proto-oncogene (CBL) 抗体
Cbl proto-oncogene (Cbl) 抗体
4732447J05Rik 抗体
c-Cbl 抗体
C-CBL 抗体
c-cbl-like 抗体
cbl 抗体
Cbl-2 抗体
CBL2 抗体
FRA11B 抗体
NSLL 抗体
RGD1561386 抗体
RNF55 抗体
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