CBFA2T2 产品
(Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2))
Categories
In acute myeloid leukemia, especially in the M2 subtype, the t(8\;21)(q22\;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008].
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Featured CBFA2T2 Categories
CBFA2T2 抗体
High quality antibodies with extensive validation data.
CBFA2T2 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CBFA2T2 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p)
Validations
- (4)
Cat. No.
ABIN522603
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (3)
Cat. No.
ABIN522600
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (3)
Cat. No.
ABIN522599
Quantity
50 μg
Datasheet
Datasheet
Recommended CBFA2T2 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1348158
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1348157
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3131988
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our CBFA2T2 Products
: "Novel binding partners of Ldb1 are required for haematopoietic development." in: Development (Cambridge, England), Vol. 133, Issue 24, pp. 4913-23, (2006) (PubMed).Synonyms and alternative names related to CBFA2T2
CBFA2/RUNX1 translocation partner 2 (Cbfa2t2), CBFA2/RUNX1 translocation partner 2 (CBFA2T2), core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human) (Cbfa2t2), CBFA2/RUNX1 translocation partner 2 L homeolog (cbfa2t2.L), A430091M07, C330013D05Rik, cbfa2t2-a, Cbfa2t2h, EHT, MTGR1, p85, XETOR, ZMYND3Protein level used designations for CBFA2T2
- translocated to, 2
- myeloid translocation gene-related protein 1
- protein CBFA2T2
- CBFA2T2 identified gene homolog
- MTG8-like protein
- MTG8-related protein 1
- core-binding factor runt domain alpha subunit 2 translocated to 2 homolog
- core-binding factor, runt domain, alpha subunit 2, translocated to, 2 homolog
- ETO homolog on chromosome 20
- ETO homologous on chromosome 20
- myeloid translocation-related protein 1
- a subunit 2; translocated to, 2
- expressed during neurogenesis
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