C5 产品
(Complement Component 5 (C5))
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The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis. [provided by RefSeq, Jul 2008].
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Featured C5 Categories
C5 抗体
High quality antibodies with extensive validation data.
C5 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
C5 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended C5 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse, Rat
Application
WB, IHC (p)
Validations
- (6)
Cat. No.
ABIN3044294
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IF (p), IF (cc), IHC (p)
Validations
- (1)
- (3)
Cat. No.
ABIN727875
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, FACS
Validations
- (5)
Cat. No.
ABIN3029690
Quantity
0.4 mL
Datasheet
Datasheet
Recommended C5 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (4)
- (1)
Cat. No.
ABIN6955010
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966011
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966010
Quantity
96 tests
Datasheet
Datasheet
Recommended C5 蛋白
Latest Publications for our C5 Products
: "Impaired insulin signaling in the B10.D2-Hc0 H2d H2-T18c/oSnJ mouse model of complement factor 5 deficiency." in: American journal of physiology. Endocrinology and metabolism, Vol. 317, Issue 2, pp. E200-E211, (2020) (PubMed).: "iTRAQ-Based Proteomic Analysis Reveals Protein Profile in Plasma from Children with Autism." in: Proteomics. Clinical applications, Vol. 12, Issue 3, pp. e1700085, (2019) (PubMed).
: "SAK-HV Triggered a Short-period Lipid-lowering Biotherapy Based on the Energy Model of Liver Proliferation via a Novel Pathway." in: Theranostics, Vol. 7, Issue 6, pp. 1749-1769, (2018) (PubMed).
: "Complement C5a Receptor is the Key Initiator of Neutrophil Adhesion Igniting Immune Complex-induced Arthritis." in: Science immunology, Vol. 2, Issue 7, (2017) (PubMed).
: "Complement C5a/C5aR pathway potentiates the pathogenesis of gastric cancer by down-regulating p21 expression." in: Cancer letters, Vol. 412, pp. 30-36, (2017) (PubMed).
: "Sex matters: Systemic complement activity of female C57BL/6J and BALB/cJ mice is limited by serum terminal pathway components." in: Molecular immunology, Vol. 76, pp. 13-21, (2017) (PubMed).
: "Acute and prolonged complement activation in the central nervous system during herpes simplex encephalitis." in: Journal of neuroimmunology, Vol. 295-296, pp. 130-8, (2016) (PubMed).
: "The interaction between circulating complement proteins and cutaneous microvascular endothelial cells in the development of childhood Henoch-Schönlein Purpura." in: PLoS ONE, Vol. 10, Issue 3, pp. e0120411, (2015) (PubMed).
: "C5a/C5aR pathway is essential for the pathogenesis of murine viral fulminant hepatitis by way of potentiating Fgl2/fibroleukin expression." in: Hepatology (Baltimore, Md.), Vol. 60, Issue 1, pp. 114-24, (2014) (PubMed).
: "Using gold nanorods core/silver shell nanostructures as model material to probe biodistribution and toxic effects of silver nanoparticles in mice." in: Nanotoxicology, Vol. 8, Issue 6, pp. 686-96, (2014) (PubMed).
Synonyms and alternative names related to C5
complement C5 (C5), complement component 5 (c5), complement component 5 (C5), hemolytic complement (Hc), C5, C5a, C5b, CPAMD4, Hc, He, LOC565774, RGD1561905Protein level used designations for C5
- complement component 5
- similar to complement component C5-1
- C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
- C5a anaphylatoxin
- anaphylatoxin C5a analog
- complement C5
- prepro-C5
- anaphylatoxin
- complement component C5
- complement C5a anaphylatoxin
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