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C4A 产品

(Complement Fragment C4a (C4a))
This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].

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Featured C4A Categories

C4A 抗体

High quality antibodies with extensive validation data.

C4A ELISA试剂盒

Reliable ELISA kits for a wide range of species.

C4A 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended C4A 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application IHC, ELISA, Coat, StM
Validations
  • (4)
Cat. No. ABIN6940808
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (3)
Cat. No. ABIN7440377
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse
Application WB, IHC, IP, ICC
Validations
  • (2)
Cat. No. ABIN7431716
Quantity 100 μL
Datasheet Datasheet

Recommended C4A ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (6)
  • (1)
Cat. No. ABIN6955046
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6966053
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6966051
Quantity 96 tests
Datasheet Datasheet

Recommended C4A 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7122475
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1347536
Quantity 10 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7505492
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our C4A Products

Mattei, Ivanov, Ferrai, Jordan, Guneykaya, Buonfiglioli, Schaafsma, Przanowski, Deuther-Conrad, Brust, Hesse, Patt, Sabri, Ross, Eggen, Boddeke, Kaminska, Beule, Pombo, Kettenmann, Wolf: "Maternal immune activation results in complex microglial transcriptome signature in the adult offspring that is reversed by minocycline treatment." in: Translational psychiatry, Vol. 7, Issue 5, pp. e1120, (2018) (PubMed).

Arya, Emri, Synowsky, Shirran, Barzegar-Befroei, Peto, Botting, Lengyel, Stewart: "Quantitative analysis of hydroxyapatite-binding plasma proteins in genotyped individuals with late-stage age-related macular degeneration." in: Experimental eye research, Vol. 172, pp. 21-29, (2018) (PubMed).

Törnqvist, Jarsjö, Thorslund, Rao, Basu, Destouni: "Mechanisms of basin-scale nitrogen load reductions under intensified irrigated agriculture." in: PLoS ONE, Vol. 10, Issue 3, pp. e0120015, (2015) (PubMed).

Ding, Qiu, Li, Wang, Wang: "Novel Photoresponsive Linear, Graft, and Comb-Like Copolymers with Azobenzene Chromophores in the Main-Chain and/or Side-Chain: Facile One-Pot Synthesis and Photoresponse Properties." in: Macromolecular rapid communications, Vol. 36, Issue 17, pp. 1578-84, (2015) (PubMed).

Gao, Xuan, Yang, Liu, Liu, He: "Identification of altered plasma proteins by proteomic study in valvular heart diseases and the potential clinical significance." in: PLoS ONE, Vol. 8, Issue 8, pp. e72111, (2013) (PubMed).

Ma, Luo, Wu, Chen, Kou, Wang: "Circulation levels of acute phase proteins in patients with Takayasu arteritis." in: Journal of vascular surgery, Vol. 51, Issue 3, pp. 700-6, (2010) (PubMed).

Liang, Zhang, Wang: "Alternative complement activity in the egg cytosol of amphioxus Branchiostoma belcheri: evidence for the defense role of maternal complement components." in: PLoS ONE, Vol. 4, Issue 1, pp. e4234, (2009) (PubMed).

Wang, Zhang, Wang, An: "Complement activity in the egg cytosol of zebrafish Danio rerio: evidence for the defense role of maternal complement components." in: PLoS ONE, Vol. 3, Issue 1, pp. e1463, (2008) (PubMed).

Pfeifer, Brems, Brunson, Hugli: "Plasma C3a and C4a levels in liver transplant recipients: a longitudinal study." in: Immunopharmacology, Vol. 46, Issue 2, pp. 163-74, (2000) (PubMed).

Pfeifer, Kawahara, Hugli: "Possible mechanism for in vitro complement activation in blood and plasma samples: futhan/EDTA controls in vitro complement activation." in: Clinical chemistry, Vol. 45, Issue 8 Pt 1, pp. 1190-9, (1999) (PubMed).

Synonyms and alternative names related to C4A

complement C4A (Rodgers blood group) (C4A), complement component 4A (Rodgers blood group) (C4a), C4, C4-1, C4A2, C4A3, C4A4, C4A6, C4AD, C4b, C4S, CO4, CPAMD2, RG, Slp

Protein level used designations for C4A

  • C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2
  • C4A anaphylatoxin
  • Rodgers form of C4
  • acidic C4
  • acidic complement C4
  • complement C4-A
  • sex-limited protein
  • complement C4
  • complement component 4 (within H-2S)
  • complement component 4, gene 1
  • complement component 4B (Chido blood group)
  • complement component 4B (Childo blood group)
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