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C-Type Lectin Domain Family 4, Member M 抗体

(C-Type Lectin Domain Family 4, Member M (CLEC4M))
This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835\; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009].
C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 242-399) 抗体 C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 242-399) 抗体 C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 242-399) 抗体 (ABIN7441907)

CLEC4M 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 237-399) 抗体 C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 237-399) 抗体 C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 237-399) 抗体 (ABIN7193339)

CLEC4M 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 8A1B3 unconjugated

C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 271-320) 抗体 C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 271-320) 抗体 C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 271-320) 抗体 (ABIN7189476)

CLEC4M 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

C-Type Lectin Domain Family 4, Member M 抗体 by 适用

Find C-Type Lectin Domain Family 4, Member M 抗体 for a variety of species such as anti-Human C-Type Lectin Domain Family 4, Member M, anti-Mouse C-Type Lectin Domain Family 4, Member M, anti-Rat C-Type Lectin Domain Family 4, Member M. The species listed below are among those available. Click on a link to go to the corresponding products.

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C-Type Lectin Domain Family 4, Member M 抗体 by 标记

Find C-Type Lectin Domain Family 4, Member M 抗体 with a specific conjugate such as Biotin, FITC, Alexa Fluor 488. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular C-Type Lectin Domain Family 4, Member M 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (8)
Cat. No. ABIN7441907
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, FACS
Validations
  • (5)
Cat. No. ABIN7193339
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7189476
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF
Validations
  • (2)
Cat. No. ABIN7146089
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application IHC, FACS
Validations
  • (2)
Cat. No. ABIN5668174
Quantity 200 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (2)
Cat. No. ABIN564490
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Monkey
Application WB, IHC, IHC (p)
Validations
  • (2)
Cat. No. ABIN203419
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC
Validations
  • (2)
Cat. No. ABIN630277
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN564489
Quantity 50 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN6745594
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN6740764
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Monkey
Application WB, IHC, IHC (p)
Validations
  • (1)
Cat. No. ABIN6755289
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN7265983
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Pig
Application WB, IHC
Validations
  • (2)
Cat. No. ABIN2775393
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Pig, Rabbit, Rat, Zebrafish (Danio rerio)
Application WB
Validations
  • (2)
Cat. No. ABIN2775394
Quantity 100 μL
Datasheet Datasheet

Latest Publications for our C-Type Lectin Domain Family 4, Member M 抗体

Swystun, Lai, Notley, Georgescu, Paine, Mewburn, Nesbitt, Schledzewski, Géraud, Kzhyshkowska, Goerdt, Hopman, Montgomery, James, Lillicrap: "The endothelial cell receptor stabilin-2 regulates VWF-FVIII complex half-life and immunogenicity." in: The Journal of clinical investigation, Vol. 128, Issue 9, pp. 4057-4073, (2018) (PubMed).

Botting, Bertram, Baharlou, Sandgren, Fletcher, Rhodes, Rana, Plasto, Wang, Lim, Barnouti, Kohout, Papadopoulos, Merten, Olbourne, Cunningham, Haniffa, Harman: "Phenotypic and functional consequences of different isolation protocols on skin mononuclear phagocytes." in: Journal of leukocyte biology, Vol. 101, Issue 6, pp. 1393-1403, (2017) (PubMed).

Mukherjee, Dowd, Manhart, Ledgerwood, Durbin, Whitehead, Pierson: "Mechanism and significance of cell type-dependent neutralization of flaviviruses." in: Journal of virology, Vol. 88, Issue 13, pp. 7210-20, (2014) (PubMed).

Rydz, Swystun, Notley, Paterson, Riches, Sponagle, Boonyawat, Montgomery, James, Lillicrap: "The C-type lectin receptor CLEC4M binds, internalizes, and clears von Willebrand factor and contributes to the variation in plasma von Willebrand factor levels." in: Blood, Vol. 121, Issue 26, pp. 5228-37, (2013) (PubMed).

Johnson, McLellan, Graham: "Respiratory syncytial virus glycoprotein G interacts with DC-SIGN and L-SIGN to activate ERK1 and ERK2." in: Journal of virology, Vol. 86, Issue 3, pp. 1339-47, (2012) (PubMed).

Jain, Manuel, Khan, Ahuja, Quann, Wigdahl: "DC-SIGN mediates cell-free infection and transmission of human T-cell lymphotropic virus type 1 by dendritic cells." in: Journal of virology, Vol. 83, Issue 21, pp. 10908-21, (2009) (PubMed).

Crosby, Lalor, Ross, Newsome, Adams: "Adhesion of human haematopoietic (CD34+) stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4." in: Journal of hepatology, Vol. 51, Issue 4, pp. 734-49, (2009) (PubMed).

Karrar, Broomé, Uzunel, Qureshi, Sumitran-Holgersson: "Human liver sinusoidal endothelial cells induce apoptosis in activated T cells: a role in tolerance induction." in: Gut, Vol. 56, Issue 2, pp. 243-52, (2007) (PubMed).

Lai, Sun, Zhang, Jennings, Lalor, Hubscher, McKeating, Adams: "Expression of DC-SIGN and DC-SIGNR on human sinusoidal endothelium: a role for capturing hepatitis C virus particles." in: The American journal of pathology, Vol. 169, Issue 1, pp. 200-8, (2006) (PubMed).

Chaipan, Soilleux, Simpson, Hofmann, Gramberg, Marzi, Geier, Stewart, Eisemann, Steinkasserer, Suzuki-Inoue, Fuller, Pearce, Watson, Hoxie, Baribaud, Pöhlmann: "DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets." in: Journal of virology, Vol. 80, Issue 18, pp. 8951-60, (2006) (PubMed).

Aliases for C-Type Lectin Domain Family 4, Member M 抗体

C-type lectin domain family 4 member M (CLEC4M) 抗体
CD209B 抗体
CD209L 抗体
CD299 抗体
DC-SIGN2 抗体
DC-SIGNR 抗体
DCSIGNR 抗体
HP10347 抗体
L-SIGN 抗体
LSIGN 抗体
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