C-Type Lectin Domain Family 4, Member M 产品
(C-Type Lectin Domain Family 4, Member M (CLEC4M))
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This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835\; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009].
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Featured C-Type Lectin Domain Family 4, Member M Categories
C-Type Lectin Domain Family 4, Member M 抗体
High quality antibodies with extensive validation data.
C-Type Lectin Domain Family 4, Member M ELISA试剂盒
Reliable ELISA kits for a wide range of species.
C-Type Lectin Domain Family 4, Member M 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended C-Type Lectin Domain Family 4, Member M 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (8)
Cat. No.
ABIN7441907
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, FACS
Validations
- (5)
Cat. No.
ABIN7193339
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7189476
Quantity
100 μg
Datasheet
Datasheet
Recommended C-Type Lectin Domain Family 4, Member M ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6965274
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6385420
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN4882575
Quantity
96 tests
Datasheet
Datasheet
Recommended C-Type Lectin Domain Family 4, Member M 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1349664
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
Cat. No.
ABIN7504305
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
Cat. No.
ABIN7504304
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our C-Type Lectin Domain Family 4, Member M Products
: "The endothelial cell receptor stabilin-2 regulates VWF-FVIII complex half-life and immunogenicity." in: The Journal of clinical investigation, Vol. 128, Issue 9, pp. 4057-4073, (2018) (PubMed).: "Phenotypic and functional consequences of different isolation protocols on skin mononuclear phagocytes." in: Journal of leukocyte biology, Vol. 101, Issue 6, pp. 1393-1403, (2017) (PubMed).
: "Mechanism and significance of cell type-dependent neutralization of flaviviruses." in: Journal of virology, Vol. 88, Issue 13, pp. 7210-20, (2014) (PubMed).
: "The C-type lectin receptor CLEC4M binds, internalizes, and clears von Willebrand factor and contributes to the variation in plasma von Willebrand factor levels." in: Blood, Vol. 121, Issue 26, pp. 5228-37, (2013) (PubMed).
: "Respiratory syncytial virus glycoprotein G interacts with DC-SIGN and L-SIGN to activate ERK1 and ERK2." in: Journal of virology, Vol. 86, Issue 3, pp. 1339-47, (2012) (PubMed).
: "DC-SIGN mediates cell-free infection and transmission of human T-cell lymphotropic virus type 1 by dendritic cells." in: Journal of virology, Vol. 83, Issue 21, pp. 10908-21, (2009) (PubMed).
: "Adhesion of human haematopoietic (CD34+) stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4." in: Journal of hepatology, Vol. 51, Issue 4, pp. 734-49, (2009) (PubMed).
: "Human liver sinusoidal endothelial cells induce apoptosis in activated T cells: a role in tolerance induction." in: Gut, Vol. 56, Issue 2, pp. 243-52, (2007) (PubMed).
: "Expression of DC-SIGN and DC-SIGNR on human sinusoidal endothelium: a role for capturing hepatitis C virus particles." in: The American journal of pathology, Vol. 169, Issue 1, pp. 200-8, (2006) (PubMed).
: "DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets." in: Journal of virology, Vol. 80, Issue 18, pp. 8951-60, (2006) (PubMed).
Synonyms and alternative names related to C-Type Lectin Domain Family 4, Member M
C-type lectin domain family 4 member M (CLEC4M), CD209B, CD209L, CD299, DC-SIGN2, DC-SIGNR, DCSIGNR, HP10347, L-SIGN, LSIGNProtein level used designations for C-Type Lectin Domain Family 4, Member M
- C-type lectin domain family 4 member M
- CD209 antigen-like protein 1
- CD299 antigen
- DC-SIGN-related protein
- dendritic cell-specific ICAM-3-grabbing non-integrin 2
- liver/lymph node-specific ICAM-3 grabbing non-integrin
- liver/lymph node-specific ICAM-3-grabbing non-integrin
- mannose binding C-type lectin DC-SIGNR
- CD209b antigen
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